What causes mutation of 5-methylcytosine to thymine?
What causes mutation of 5-methylcytosine to thymine? The DNA of many bacterial and eukaryotic species contains 5-methylcytosine (5meC) in addition to cytosine. Deamination of 5meC produces thymine, which is not recognized by uracil glycosylase and consequently can result in C → T mutations. Why the deamination of 5-methylcytosine leads to hot spots for spontaneous mutations […]