How does DKK1 inhibit Wnt?
How does DKK1 inhibit Wnt? DKK1 inhibits β‐catenin‐dependent Wnt signalling by binding to the LRP5/6 co‐receptor and blocking Wnt binding, which results in β‐catenin degradation. How is DKK1 secreted? DKK-1 is a central regulator of osteoblast activity and osteoblastic bone metastasis and is likely dually dependent on the downregulation of microenvironment DKK-1 secretion from: (1) […]