What does U1 snRNA do?
What does U1 snRNA do? Briefly, U1-snRNP initiates assembly of the spliceosome onto pre-mRNA through binding to the 5′ pre-mRNA splice site, followed by the ATP-dependent binding of U2-snRNP at the branch site where cleavage occurs (8, 26). Where does U1 snRNA bind? U1 snRNP binds to the 5′ exon-intron junction of pre-mRNA and thus […]