What isvdvdj recombinase?
What isvdvdj recombinase?
VDJ recombinase refers to a collection of enzymes some of which are lymphocyte specific, and some that are expressed in many cell types. The initial steps of VDJ recombination are carried out by critical lymphocyte specific enzymes, called recombination activating gene -1 and -2 (RAG1 and RAG2).
How is the VDJ gene rearranged?
This D-J recombination is followed by the joining of one V gene, from a region upstream of the newly formed DJ complex, forming a rearranged VDJ gene. All other genes between V and D segments of the new VDJ gene are now deleted from the cell’s genome.
What is V(D)J recombination and how does it work?
*Corresponding author. V (D)J recombination assembles immunoglobulin and T cell receptor genes during lymphocyte development through a series of carefully orchestrated DNA breakage and rejoining events.
What are the enzymes involved in VDJ?
The initial steps of VDJ recombination are carried out by critical lymphocyte specific enzymes, called recombination activating gene -1 and -2 (RAG1 and RAG2). These enzymes associate with each other to recognize the RSS sequences and induce DNA cleavage at the RSS sequences.
