What are the therapeutic classification of drugs with their categories?
What are the therapeutic classification of drugs with their categories?
USP Therapeutic Categories Model Guidelines
| Therapeutic Category | Pharmacologic Class | Formulary Key Drug Types |
|---|---|---|
| Analgesics | Opioid Analgesics, Short-acting | |
| Anesthetics | Local Anesthetics | |
| Antibacterials | Aminoglycosides | |
| Beta-lactam, Cephalosporins | Cephalosporin Antibacterials, 1st Generation |
When a drug has a low therapeutic index that drug should be?
The larger the therapeutic index (TI), the safer the drug is. If the TI is small (the difference between the two concentrations is very small), the drug must be dosed carefully and the person receiving the drug should be monitored closely for any signs of drug toxicity.
What is therapeutic index of any drug?
The therapeutic index (TI; also known as therapeutic ratio) is a ratio that compares the blood concentration at which a drug causes a therapeutic effect to the amount that causes death (in animal studies) or toxicity (in human studies) [1].
What are therapeutic drugs and examples?
What is it used for?
| Types of Medicine | Medicine Names |
|---|---|
| Antibiotics | vancomycin, gentamycin, amakacin |
| Heart drugs | digoxin, procainamide, lidocaine |
| Anti-seizure drugs | phenytoin, phenobarbital |
| Drugs treat autoimmune diseases | cyclosporine, tacrolimus |
What is the meaning of narrow therapeutic index?
Introduction. Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What is ed50 and td50?
ED50 is the dose required to produce a therapeutic effect in 50% of the population; TD50 is the dose required to produce a toxic effect in 50% of the population; both are calculated from dose–response curves. The therapeutic index is shown in Figure 18.7. Figure 18.7.
What does low distribution mean?
This means that most of the drug is in the tissue, and very little is in the plasma circulating. The larger the volume of distribution, the more likely that the drug is found in the tissues of the body. The smaller the volume of distribution, the more likely that the drug is confined to the circulatory system.
What is a narrow therapeutic index drug?
Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What are the 7 major classes of therapeutic drugs?
7 Drug Categories
- (1) Central Nervous System (CNS) Depressants. CNS depressants slow down the operations of the brain and the body.
- (2) CNS Stimulants.
- (3) Hallucinogens.
- (4) Dissociative Anesthetics.
- (5) Narcotic Analgesics.
- (6) Inhalants.
- (7) Cannabis.
What medications have a narrow therapeutic index?
Narrow Therapeutic Index (NTI) is a very close margin between the concentration in the blood circulation of a drug that is therapeutic and the concentration that is lethal (deadly). Pharmacists generally express the therapeutic index as a ratio between the median effective dose (ED50) and the median lethal dose (LD50).
How do you calculate therapeutic index?
When animal studies are used to calculate the therapeutic index, the process is slightly different. In this case, the dose that causes 50 percent of the animals in the study to die, or the LD50, is used for the equation. The therapeutic ratio is then found by dividing the LD50 by the ED50.
Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What is a high therapeutic index?
A high therapeutic index is good ! The Therapeutic Index of a drug is the ratio of the toxic to the therapeutic dose. Drugs with a low therapeutic index may only require a small increase in dose to produce toxic effects.
