What is the function of VDR gene?

What is the function of VDR gene?

The VDR gene provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond to vitamin D. This vitamin can be acquired from foods in the diet or made in the body with help from sunlight exposure.

Is VDR a protein?

VDR (Vitamin D Receptor) is a Protein Coding gene. Diseases associated with VDR include Vitamin D-Dependent Rickets, Type 2A and Rickets. Among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Regulation of nuclear SMAD2/3 signaling.

What is VDR polymorphism?

Expression and nuclear activation of the vitamin D receptor (VDR) are necessary for the effects of vitamin D. Several genetic variations have been identified in the VDR. DNA sequence variations, which occur frequently in the population, are referred to as “polymorphisms” and can have biological effects.

What is e vitamin D binding DBP?

Vitamin D binding protein (DBP) is the major carrier protein of 25-hydroxyvitamin D (25(OH) D) in the circulation, where it may serve roles in maintaining stable levels during times of decreased 25(OH) availability and in regulating delivery of 25(OH) D to target tissues.

What is a VDR agonist?

Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types. More recently, it has become clear that VDR agonists possess immunoregulatory properties and, in particular, pronounced protolerogenic activities.

Where is VDR located?

In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13. 11. VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals.

How is VDR gene regulated?

The VDR is regulated at both transcriptional and posttranslational levels. VDR gene expression is up-regulated in NIH-3T3 mouse fibroblasts through activation of the protein kinase A pathway (27) and down-regulated through activation of the protein kinase C pathway (28).

Where is VDR?

What is VDR BSM?

VDR BSM +/+ is protective against cancer because it up-regulates the conversion of Vitamin D to the active form [Vitamin D 1,25], but when a person with the BSM mutation takes too much vitamin D it can become counterproductive and some have said that it actually could cause harm because it can lead…

Is vitamin D deficiency genetic?

Supplements are a good way to make up for a genetic lack of vitamin D. Recent genetic findings have come out to support observational evidence that low levels of vitamin D are associated with an increased risk of multiple sclerosis.

What is a receptor gene?

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.