What is Fosphenytoin 100mg used for?
What is Fosphenytoin 100mg used for?
Cerebyx (fosphenytoin sodium) Injection is an anti-epileptic drug, also called an anticonvulsant, used to prevent or control seizures. Cerebyx is used only for a short time, such as 5 days, when other forms of phenytoin cannot be given.
How is Fosphenytoin administered?
Intravenous: When fosphenytoin is administered by IV infusion, maximum plasma fosphenytoin concentrations are achieved at the end of the infusion. Fosphenytoin has a half-life of approximately 15 minutes. Intramuscular: Fosphenytoin is completely bioavailable following IM administration of fosphenytoin.
How do you prepare phenytoin infusion?
For administration by intravenous infusion phenytoin injection should be diluted in 50 – 100 ml of normal saline, and the final concentration of phenytoin in the solution should not exceed 10 mg/ml, the infusion mixture should not be refrigerated.
What mg does phenobarbital come in?
The 15 mg, 30 mg, 60 mg, and 100 mg tablets of phenobarbital are not currently available from the generic manufacturer, West-ward, or distributors. Other strengths are still available, including the 16.2 mg, 32.4 mg, 64.8 mg, and 97.2 mg tablets. The phenobarbital oral liquid is also still available.
What’s the other name for Keppra?
Levetiracetam (lev-eh-teer-ASS-eh-tam) is the generic name (non-brand name) for the drug called Keppra (KEP-ruh). Keppra is a widely used seizure medicine from UCB.
Do you dilute Fosphenytoin?
DOSAGE AND ADMINISTRATION Products with particulate matter or discoloration should not be used. Prior to IV infusion, dilute Cerebyx in 5% dextrose or 0.9% saline solution for injection to a concentration ranging from 1.5 to 25 mg PE/mL.
How do you monitor Fosphenytoin?
1. Continuous telemetry monitoring with blood pressure measurement at a minimum of every 15 minutes is required for administration of fosphenytoin IV doses greater than 300 mg PE and should be continued for 10 to 20 minutes after the infusion is completed.
When do you get Fosphenytoin level?
After a patient has received a loading dose of intravenous phenytoin, levels can be checked one hour after the dose. If loading is achieved by oral dosing, phenytoin levels can be checked 24 hours after the last dose10. This level can aid in determining maintenance dose or need to reload.
What pH is phenytoin infusion?
The commercially available injectable products con tain phenytoin sodium 50 mg/mL, 40N propylene glycol, 107( alcohol, and water for injection, with so dium hydroxide added to achieve a pH of 10.0-12.3.
How do you calculate phenytoin?
If clcr < 20 mL/min then Corrected Phenytoin = Total Phenytoin Level / ( (0.1 x albumin) + 0.1) This is so cool!
How much phenobarbital can a human take?
Geriatric Adults 100 mg to 200 mg PO once daily at bedtime is usual adult dosage. Use a reduced dosage in geriatric patients due to increased sensitivity to drug effects. Barbiturates may be associated with marked excitement, depression, or confusion in geriatric patients.
How much phenytoin is in a PE of fosphenytoin?
Fosphenytoin is dosed in phenytoin equivalents (PE) 1 PE fosphenytoin = 1 mg phenytoin sodium = 1.5 mg fosphenytoin sodium . Adults: Status Epilepticus: 18 to 20 mg PE/kg IV Repetitive seizure: 18 to 20 mg PE/kg IV Loading dose: 18 to 20 mg PE/kg given IV or IM NOTE: Loading dose in obese patients may be calculated based on the
What is the loading dose of fosphenytoin sodium injection?
The loading dose of Fosphenytoin Sodium Injection is 15 to 20 mg PE/kg administered at 100 to 150 mg PE/min.
What are the contraindications for fosphenytoin sodium?
Fosphenytoin Sodium Injection is contraindicated in patients with: A history of hypersensitivity to Fosphenytoin Sodium Injection or its inactive ingredients, or to phenytoin or other hydantoins [see Warnings and Precautions (5.6)]. Sinus bradycardia, sino-atrial block]
How many milligrams of phenytoin can you give a 17 year old?
Less than 17 years: 15 to 20 mg PE/kg IV at a rate of 2 mg PE/kg/min (or 150 mg PE/min, whichever is slower) followed by maintenance doses of either fosphenytoin or phenytoin. Comments: -The dose, concentration, and infusion rate of this drug should always be expressed as phenytoin sodium equivalents (PE).
