What is IIb IIIa antibody?
What is IIb IIIa antibody?
In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation.
How is GPIIb IIIa activated?
Shear-induced activation of the GPIIb/IIIa is initiated by the interaction of GPIbα with VWF immobilized to the exposed subendothelium of the injured vessel wall, especially in the atherosclerotic plaque rupture, leading to platelet-surface adhesion.
What does gp IIb IIIa do?
Glycoprotein IIb/IIIa (GPIIb/IIIa) plays a major role in the regulation of platelet adhesion and aggregation during haemostasis. Upon platelet activation by an agonist a signalling process is initiated, termed “inside-out” signalling, which gives rise to conformational changes within GPIIb/IIIa.
Which of the following drugs is an inhibitor of platelet glycoprotein IIb IIIa receptors by blocking the binding of fibrinogen and von Willebrand factor?
Eptifibatide (Integrilin) is an antagonist of the platelet GP IIb/IIIa receptor; it reversibly prevents von Willebrand factor, fibrinogen, and other adhesion ligands from binding to the GP IIb/IIIa receptor.
How do you reverse heparin-induced thrombocytopenia?
Thrombocytopenia should be treated with transfusion of washed platelets. Excessive anticoagulation associated with danaparoid can completely be reversed with protamine sulfate. In patients with a history of HIT, heparin can safely be used intraoperatively during cardiac surgery.
How do you know if you have heparin-induced thrombocytopenia?
HIT can often be diagnosed by measuring the platelet count and PF4 antibody level in the blood. Symptoms of new blood clot formation may suggest HIT. Symptoms of deep vein thrombosis include pain or tenderness, sudden swelling, discoloration, visibly large veins, and skin that is warm to the touch.
What are the generalities of glycoprotein IIb/IIIa inhibitors?
Glycoprotein IIb/IIIa inhibitors—generalities. The glycoprotein (GP) IIb/IIIa receptor is an integrin that mediates the final common pathway of platelet aggregation. In particular, the GP IIb/IIIa receptor is a heterodimer consisting of the alpha IIb and beta3-subunits.
What happens when the GP IIb/IIIa complex is activated?
Calcium mobilization, tyrosine phosphorylation, activation of phosphoinositide metabolism, and cytoskeletal reorganization result from the activation of the GP IIb/IIIa complex. This series of events transforms platelet aggregation from a reversible to an irreversible process.
How do glycoprotein IIb/IIIa receptor blockers (tirofiban) work?
Glycoprotein IIb/IIIa receptor blockers (tirofiban, lamifiban, epifibatide, abciximab) inhibit platelet aggregation by preventing the binding of fibrinogen and the von Willebrand factor (and other adhesive molecules) to glycoprotein IIb/IIIa receptors on the surface of activated platelets.
Where can I find platelet glycoprotein – GPIIb/IIIa antibody?
Affinity Biologicals, Inc. manufactures a Platelet Glycoprotein – GPIIb/IIIa Antibody which can be found in the listing below. Further information about our Platelet Glycoprotein – GPIIb/IIIa polyclonal antibody is available by following the links below.
