How is bone fibrous dysplasia diagnosed?

How is bone fibrous dysplasia diagnosed?

The primary tool for diagnosis of fibrous dysplasia is an X-ray. While bone appears solid in an X-ray, a fibrous dysplasia lesion has a relative distinct appearance often described as “ground glass.” The condition may be diagnosed, therefore, even in a person with no symptoms who is getting an X-ray for other reasons.

What is ground glass appearance in fibrous dysplasia?

A typical FD lesion in the axial skeleton appear as an area of radiolucent ground glass matrix, which is usually smooth and homogeneous, not centrally located within medullary bone. Craniofacial FD typically demonstrates dense and sclerotic lesions (Fig. 4).

Is fibrous dysplasia radiolucent?

Among these imaging techniques, there are key features that are examined in order to more easily identify the presence of fibrous dysplasia. The abnormal growth of lesions can often be identified as either radiolucent or radiopaque or a mixture of both [2].

What causes bones to protrude?

Causes of Bone Spurs The most common cause of bone spurs is joint damage from osteoarthritis or degenerative joint disease. The cushioning between your joints and the bones of your spine can wear down with age. Rheumatoid arthritis, lupus, and gout can also damage your joints.

What is ground-glass appearance of bone?

Usually, the matrix of the lucency is smooth and relatively homogeneous; classically, this finding is described as a ground-glass appearance. Irregular areas of sclerosis may be present with or without calcification. The lucent lesion has a thick sclerotic border and is called the rind sign.

What is moth eaten appearance?

If you describe something as moth-eaten, you mean that it seems unattractive or useless because it is old or has been used too much.

What is fibrous dysplasia?

Fibrous dysplasia is a chronic problem in which scar-like tissue grows in place of normal bone. It often results in one or more, of the following: Bone deformity. Brittle bones.

How does fibrous dysplasia affect the skeletal system?

Fibrous dysplasia (FD) is a rare bone disorder. Bone affected by this disorder is replaced by abnormal scar-like (fibrous) connective tissue. This abnormal fibrous tissue weakens the bone, making it abnormally fragile and prone to fracture. Pain may occur in the affected areas.

What is the histology of fibrous dysplasia?

Fibrous dysplasia has a classic histology of low to moderately cellular fibrous stroma surrounding irregular, curvilinear trabeculae of woven bone, which is arranged in a pattern commonly referred to as “resembling Chinese characters” ( Figure 3 ).

What are fibrous dysplasia trabeculae composed of?

The trabeculae in fibrous dysplasia are composed of woven bone with various phases of mineralization. Mature lamellar bone can be seen at the periphery but should not be part of the lesion itself.

Is Azan and toluidine blue staining associated with dysplasia and ossifying fibroma?

Fibrous dysplasia (FD) and ossifying fibroma (OF) are fibro-osseous lesions (FOLs) having several overlaps that may make final diagnosis difficult by hematoxylin and eosin (H/E) alone. This study seeks to detect any association between Azan and Toluidine blue staining as compared with osteocalcin in FD and OF diagnosis.

What is fibro-osseous lesion?

Definition / general 1 Benign fibro-osseous lesion that may involve one (monostotic) or multiple (polyostotic) bones 2 Developmental disorder of bone resulting in the failure to form mature lamellar bone 3 Mass forming developmental defect composed of woven bone and fibroblast-like spindle cells