What are ganglion cells in the colon?
What are ganglion cells in the colon?
Ganglion cells are required to allow receptive relaxation of the bowel. They are derived from the neural crest and populate the plexuses of Auerbach and Meissner within the bowel wall (Fig. 12-1). Neural crest cells originate in the proximal intestine and migrate distally during development, populating the rectum last.
What is the function of the ganglion cell?
Retinal ganglion cells process visual information that begins as light entering the eye and transmit it to the brain via their axons, which are long fibers that make up the optic nerve. There are over a million retinal ganglion cells in the human retina, and they allow you to see as they send the image to your brain.
What is the pathophysiology of Hirschsprung disease?
Hirschsprung disease results from the absence of enteric neurons within the myenteric and submucosal plexus of the rectum and/or colon. Enteric neurons are derived from the neural crest and migrate caudally with the vagal nerve fibers along the intestine.
Is Hirschsprung’s disease genetic?
The genetic cause of the condition is unknown in approximately half of affected individuals. Mutations in the RET gene are the most common known genetic cause of Hirschsprung disease. The RET gene provides instructions for producing a protein that is involved in signaling within cells.
What is ganglion cells in Hirschsprung’s disease?
Hirschsprung’s disease (also called congenital aganglionic megacolon) occurs when some of your baby’s intestinal nerve cells (ganglion cells) don’t develop properly, delaying the progression of stool through the intestines.
What do ganglion cells respond to?
Ganglion cells show diverse responses to step changes of light (Figure 1(a)). Generally, responses can be divided into ON (activated by increases of light intensity), OFF (activated by decreases of light intensity), and ON–OFF (activated by both increases and decreases of light intensity).
