What are biologically active flavonoids?
What are biologically active flavonoids?
Abstract. Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants and diets. They are believed to have various bioactive effects including anti-viral, anti-inflammatory, cardioprotective, anti-diabetic, anti-cancer, anti-aging, etc.
Are flavonoid supplements safe?
The consumer may have the misperception that dietary flavonoid supplements are devoid of toxicity and, therefore, they are safe to use because these compounds are “natural” (104).
What are potential pharmaceutical uses for flavonoid compounds?
The examples of these phytochemicals from several medicinal plants are also illustrated, and their potential applications in pharmaceutical and medical aspects, especially for health promoting e.g., antioxidant effects, antibacterial effect, anti-cancer effect, cardioprotective effects, immune system promoting and anti …
Are flavonoids bioactive?
Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants and diets. They are believed to have various bioactive effects including anti-viral, anti-inflammatory, cardioprotective, anti-diabetic, anti-cancer, anti-aging, etc.
How do flavonoids work as antioxidants?
Flavonoids are phenolic substances isolated from a wide range of vascular plants, with over 8000 individual compounds known. However, most interest has been devoted to the antioxidant activity of flavonoids, which is due to their ability to reduce free radical formation and to scavenge free radicals.
What are the main groups of flavonoids?
There are several significant groups of flavonoids, including anthocyanidins, flavanols, flavones, flavonols, flavonones and isoflavones. Within the flavanol subgroup there are still more subgroups.
Are flavonoids harmful?
While most flavonoids/phenolics are considered safe, flavonoid/phenolic therapy or chemopreventive use needs to be assessed as there have been reports of toxic flavonoid-drug interactions, liver failure, contact dermatitis, hemolytic anemia, and estrogenic-related concerns such as male reproductive health and breast …
What are the benefits of flavonoids?
Phytonutrients like flavonoids have beneficial anti-inflammatory effects and they protect your cells from oxidative damage that can lead to disease. These dietary antioxidants can prevent the development of cardiovascular disease, diabetes, cancer, and cognitive diseases like Alzheimer’s and dementia.
How relevant are flavonoids as antioxidants in plants?
Most flavonoids outperform well-known antioxidants, such as ascorbate (vitamin C) and alpha-tocopherol (vitamin E), in in vitro antioxidant assays because of their strong capacity to donate electrons or hydrogen atoms.
What is the difference between antioxidants and flavonoids?
Though flavonoids exhibit powerful antioxidant activity, they exist in a relatively low concentration in the bloodstream when compared to antioxidants like vitamin C and vitamin E, according to World’s Healthiest Foods. This may lower their overall antioxidant power, and thus lessen their cancer-fighting effects.
What are the 6 major subclasses of flavonoids?
Flavonoid Subclasses Flavonoids are classified into 12 major subclasses based on chemical structures, six of which, namely anthocyanidins, flavan-3-ols, flavonols, flavones, flavanones, and isoflavones (Table 1 and Figures 1-9) are of dietary significance.
What are the antibacterial effects of flavonoids?
Some synthetic derivatives of flavonoids also exhibited remarkable antibacterial activities with 20- to 80-fold more potent activity than the standard drug against multidrug-resistant Gram-negative and Gram-positive bacteria (including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus ).
Why are flavonoids so popular as dietary supplements?
Recently, a renewed interest in flavonoids has been fueled by the antioxidant and estrogenic effects ascribed to them. This has led to their proposed use as anticarcinogens and cardioprotective agents, prompting a dramatic increase in their consumption as dietary supplements.
Are plant flavonoids mutagenic?
Potential health impacts of excessive flavonoid intake Plant flavonoids are common dietary components that have many potent biological properties. Early studies of these compounds investigated their mutagenic and genotoxic activity in a number of in vitro assays.
What are flavonoids (Vitamin P)?
Flavonoids, sometimes called vitamin P, are found in lots of different fruits and vegetables. They might have benefits for your health. Flavonoids are a large group of plant chemicals naturally found in many foods.
