What does the word Enterohepatic mean?

What does the word Enterohepatic mean?

: of or involving the intestine and the liver enterohepatic circulation of bile salts.

How does enterohepatic circulation affect bioavailability?

Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation. Bioavailability is also affected by the extent of intestinal absorption, gut-wall P-glycoprotein efflux and gut-wall metabolism.

What are the differences between first pass effect and enterohepatic circulation?

The first-pass effect describes inactivation of a drug during the first liver passage. The enterohepatic circulation is a cyclic process of biliary elimination and consequent intestinal reabsorption of a drug.

How are bile salts recycled through the enterohepatic circulation?

Approximately 94% of the bile salts are reabsorbed at special mucosal receptor sites in the distal ileum and reused by the liver by the process of enterohepatic circulation. In enterohepatic circulation, compounds secreted in bile are reabsorbed in the gastrointestinal tract and returned to the liver.

What is enterohepatic circulation of bilirubin?

Enterohepatic circulation refers to the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.

What is entero mean?

the intestine
Entero-: Prefix referring to the intestine, as in enteropathy (a disease of the intestine) and enterospasm (a painful, intense contraction of the intestine).

What is the importance of enterohepatic circulation of drugs?

Enterohepatic circulation allows for recycling of metabolized and non-metabolized compounds, and is of critical importance in toxicologic processes involving the gastrointestinal tract.

What is enterohepatic circulation?

The term enterohepatic circulation (EHC) denotes the movement of bile acid molecules from the liver to the small intestine and back to the liver. Bile acids traverse the hepatocyte and are actively secreted into canalicular bile, completing the enterohepatic cycle.

What is bioavailability of a drug?

Bioavailability refers to the extent a substance or drug becomes completely available to its intended biological destination(s).

What causes increased enterohepatic circulation?

Decreased intestinal activity leads to increased enterohepatic circulation. Breastfeeding jaundice, breast milk jaundice, and intestinal obstruction are common conditions associated with increased enterohepatic circulation, leading to unconjugated hyperbilirubinemia.

What is increased enterohepatic circulation?

How does Enterohepatic cause jaundice?

A factor in human milk increases the enterohepatic circulation of bilirubin. Insufficient caloric intake resulting from maternal and/or infant breastfeeding difficulties may also increase serum unconjugated bilirubin concentrations. This is the infantile equivalent of adult starvation jaundice.

Why is enterophepatic circulation important?

Enterohepatic circulation allows for recycling of metabolized and non-metabolized compounds , and is of critical importance in toxicologic processes involving the gastrointestinal tract. This circulatory route is active when ingested compounds that are absorbed in the gastrointestinal tract enter the portal circulation, go to the liver, and then return to the gastrointestinal tract via biliary excretion.

What does extracorporeal circulation mean?

Extracorporeal Circulation. methods of maintaining, with special apparatus, the circulation of blood and metabolism in the body or individual parts and organs of the body at an optimum level by perfusion (passage of blood or liquid blood substitute).

What is circulation of the atmosphere?

Atmospheric circulation. Atmospheric circulation is the movement of air at all levels of the atmosphere over all parts of the planet. The driving force behind atmospheric circulation is solar energy, which heats the atmosphere with different intensities at the equator, the middle latitudes, and the poles.