What does MEK inhibitor stand for?
What does MEK inhibitor stand for?
MEK stands for MAPK/ERK kinase because of its role in activating the MAPK/ERK pathway; other names for this kinase are MAP2K and MAPKK. Because of its activity upstream of this pathway, MEK affects cellular processes such as proliferation, differentiation, and transcription.
What are MEK1 and MEK2?
MEK1 and MEK2 are dual-specificity kinases that activate ERK1 and ERK2 by phosphorylating them at conserved threonine and tyrosine residues in the T-E-Y motif found in their activation loop.
What does MEK1 stand for?
MEK1
| Acronym | Definition |
|---|---|
| MEK1 | MAP (Mitogen-Activated Protein) Kinase/ERK (Extracellular Signal-Regulated Kinase) Kinase 1 |
What is the function of MEK?
MEK is a key enzyme in the Ras/Raf/MEK/ERK signal transduction pathway and mediates cellular responses to different growth signals. This pathway is frequently deregulated in cancer, which makes these enzymes a candiate target for pharmacological antineoplastic treatment.
What are the side effects of Trametinib?
More common
- Burning, itching, and pain in hairy areas, pus at the root of the hair.
- canker sores.
- change in taste.
- dry eyes.
- dry skin.
- itching, pain, redness, swelling, tenderness, or warmth on the skin.
- loosening of the fingernails.
- loss of taste.
What is MEK medical term?
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).
What does MEK stand for?
MEK
| Acronym | Definition |
|---|---|
| MEK | Methyl Ethyl Ketone |
| MEK | Mujahadeen-e-Khalq (Iranian organization) |
| MEK | Marine Engineering Knowledge |
| MEK | Mojahedin-E Khalq Organization (Iran) |
Is MEK1 a kinase?
MEK-1 is a dual threonine and tyrosine recognition kinase that phosphorylates and activates mitogen-activated protein kinase (MAPK).
What is the MAP2K1 gene?
The identified MAP2K1 gene mutation is a germline mutation that replaces the amino acid glutamic acid with the amino acid glycine at position 102 (written as Glu102Gly or E102G) in MEK1 protein kinase. This change likely results in increased activation of the RAS/MAPK signaling pathway in cells throughout the body.
What does MEK stand for in medical terms?
| Mitogen-activated protein kinase kinase | |
|---|---|
| Identifiers | |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
How is MEK activated?
MEK itself is activated via serine phosphorylation by upstream activator kinases, including c-raf, mos and MEK kinase. These data demonstrate that MEK is activated by phosphorylation of two adjacent serine/threonine residues and this activation mechanism is conserved in the MEK family kinases.
How do you dissolve trametinib?
Trametinib is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, trametinib should first be dissolved in DMSO and then diluted with the aqueous buffer of choice.
What is the function of MAP2K2?
MAP2K2 mitogen-activated protein kinase kinase 2 [ (human)] Summary. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction.
What is another name for MEK2?
Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.
Is MEK2 expression associated with inflammation in metabolic syndrome?
High MEK2 expression is associated with inflammation. there were significant decreases in intercellular adhesion molecules 1 (ICAM1), ezrin (EZR), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3) gene expressions in metabolic syndrome patients.
What is the cytogenetic location of the MEK2 gene?
Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,090,320-4,124,183 (from NCBI) Zheng and Guan (1993) isolated and sequenced 2 human cDNAs encoding members of the MAP kinase kinase (MAP2K) family, designated MEK1 ( 176872) and MEK2 by them.
