What is ATG in stem cell transplant?

What is ATG in stem cell transplant?

BACKGROUND: Anti-thymocyte globulin (ATG) is used to prevent graft-versus-host disease (GvHD) after allogeneic haemopoietic cell transplantation (HCT). However, ATG can also cause delayed immune reconstitution of T cells, negatively affecting survival.

How long does ATG treatment last?

This allows an aplastic anemia patient’s bone marrow to rebuild its supply of bone marrow stem cells, causing blood counts to go up. Usually, ATG is given by IV infusion into a vein for 8-12 hours a day, for 4 days. The schedule depends on your needs, the type of ATG used and doctor or hospital preference.

What is ATG medication?

Introduction. Antithymocyte globulin (ATG) is an antibody preparation derived from rabbits or horses hyperimmunized with human thymocytes, which is used to prevent or treat acute cellular rejection after solid organ transplantation and as a therapy of acute aplastic anemia.

What is an autologous bone marrow transplant is a treatment for which disease?

An autologous stem cell transplant helps to replace the damaged bone marrow. An autologous stem cell transplant is most often used to treat: Hodgkin’s lymphoma. Myeloma. Non-Hodgkin’s lymphoma.

Is ATG cytotoxic?

All ATG preparations possess potent cytotoxicity against myeloma cell lines. ATG-F and Thymoglobulin have been reported to possess cytoxic effects against myeloma cells. As seen in Table II, all 4 ATG preparations showed cytotoxic activity against various myeloma cell lines.

How are Atgs made?

r-ATG is developed by injecting horses with a type of human white blood cells called thymocytes. The horse’s immune system reacts against these cells and makes antibodies that can destroy them. These antibodies are collected and purified to make r-ATG.

What should I eat if I have aplastic anemia?

To treat your anemia, your doctor may suggest eating more meat—especially red meat (such as beef or liver), as well as chicken, turkey, pork, fish, and shellfish. Nonmeat foods that are good sources of iron include: Spinach and other dark green leafy vegetables.

What is ATG full form?

ATG Full Form is Anti Thymocyte Globulin It is the type of antibody against the human T cells and ATG was derived from the horse and rabbit infusion. It used for acute rejection during organ transplantation.

Can you live a normal life after a bone marrow transplant?

Some 62% of BMT patients survived at least 365 days, and of those surviving 365 days, 89% survived at least another 365 days. Of the patients who survived 6 years post-BMT, 98.5% survived at least another year.

How painful is a bone marrow transplant?

Your bone marrow transplant occurs after you complete the conditioning process. On the day of your transplant, stem cells are infused into your body through your central line. The transplant infusion is painless. You’ll be awake during the procedure.

Does ATG affect B cells?

In addition to their T-cell-depleting properties, ATGs can modulate the immune response by affecting or interfering with the function of different immune effectors such as B lymphocytes, regulatory T lymphocytes (Treg), natural killer (NK)-T lymphocytes and dendritic cells (DC).