What is the half life of Remodulin?

What is the half life of Remodulin?

Excretion: The elimination of Remodulin is biphasic, with a terminal half-life of approximately 4 hours. Approximately 79% of an administered dose is excreted in the urine as unchanged drug (4%) and as the identified metabolites (64%). Approximately 13% of a dose is excreted in the feces.

What kind of drug is Remodulin?

Remodulin (treprostinil sodium) is a vasodilator that works by dilating (widening) the arteries used to treat pulmonary arterial hypertension (PAH). Remodulin improves the ability to exercise and prevents the condition from getting worse.

What are the side effects of Remodulin?

Nausea, vomiting, diarrhea, headache, dizziness, jaw pain, flushing, loss of appetite, weakness, abdominal pain, and redness/swelling/pain at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What is a Remodulin pump?

A small, discreet, water-resistant pump with prefilled cassettes designed to simplify the delivery of Remodulin* Learn More. *The Remunity pump can tolerate immersion in water to depths of up to 8 feet for 30 minutes and 12 feet for up to 3 minutes.

How do you administer remodulin?

Remodulin is administered subcutaneously by continuous infusion without further dilution, via a subcutaneous catheter, using an infusion pump designed for subcutaneous drug delivery.

How often is remodulin given?

Medication needs to be mixed with a diluent. Pump reservoir is usually refilled every 2 days. No infusion site pain typically seen. A Specialty Pharmacy nurse can help train you on how to use IV Remodulin and your pump.

Does remodulin make you tired?

a light-headed feeling, like you might pass out; or. worsening PAH symptoms (tiredness, pale skin, chest pain, trouble breathing).

How is remodulin administered?

How long does remodulin last?

Simple. Prefilled Remodulin cassettes help ensure you receive your intended dose of medication without the burden of mixing and are delivered to you by your Specialty Pharmacy. You can easily connect the cassette to your pump—just prime, twist, and go. Each cassette can keep you going for up to 3 days (72 hours).

How do you titrate Remodulin?

Start your patient at a dose of 1.25 ng/kg/min. Titrate up in 1.25 ng/kg/min increments per week to achieve a dose that improves PAH symptoms while minimizing excessive pharmacologic effects of Remodulin (ie, headache, nausea, emesis, restlessness, anxiety, and infusion site pain or reaction).

Does Remodulin need to be refrigerated?

When premixing for storing, Remodulin should be mixed with a sterile high-pH glycine diluent. Remodulin cannot be stored for 14 days when mixed with Sterile Water for Injection or Sodium Chloride Injection (only 4 hours at room temperature or 24 hours refrigerated).

Can Remodulin cause stomach pain?

SIDE EFFECTS: Nausea, vomiting, diarrhea, headache, dizziness, jaw pain, flushing, loss of appetite, weakness, abdominal pain, and redness/swelling/pain at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What are the side effects of Remodulin IV infusion?

IV infusion of Remodulin delivered through an external pump has been associated with the risk of blood stream infections, arm swelling, tingling sensations, bruising, and pain. The most common side effects seen with either SC or IV Remodulin were headache, diarrhea, nausea, rash, jaw pain,…

How many pumps will I receive when starting Remodulin?

When starting Remodulin, all patients will receive 2 pumps so they always have a backup pump available if needed. Start here to stay informed. Sign up to receive updates on new pumps and Remodulin news.

Should I Disconnect my infusion pump for an MRI?

Be sure to coordinate with your PAH healthcare team if an MRI is needed. The FDA recommends removing infusion pumps for any kind of radiographic studies, including MRI procedures. Temporarily disconnecting your device for these exams may be necessary to prevent radiation exposure. Always talk to your PAH doctor before disconnecting your pump.

What should I know about Remodulin before taking it?

Have liver or kidney problems. Your Remodulin dose may need to be adjusted if you have liver problems. Have low blood pressure or bleeding problems. Are taking gemfibrozil (for high cholesterol), rifampin (for infection) or other drugs that affect liver enzymes. Your doctor may need to adjust your Remodulin dosage.