What kind of cancer gene is TP53?
What kind of cancer gene is TP53?
An inherited TP53 mutation is known as Li-Fraumeni syndrome. Li-Fraumeni syndrome is a rare genetic condition that can increase your risk of certain types of cancers. These cancers include breast cancer, bone cancer, leukemia, and soft tissue cancers, also called sarcomas.
Is there a cure for Li Fraumeni syndrome?
At this time, there is no standard treatment or cure for LFS or a germline TP53 gene variant. With some exceptions, cancers in people with LFS are treated the same as for cancers in other patients, but research continues on how to best manage those cancers involved in LFS.
What is a tumor suppressor protein?
Definition. Tumour-suppressor proteins act to alleviate the potential for cancer and tumour formation by modulating cell growth either through negative regulation of the cell cycle or by promoting apoptosis.
What is the role of Blimp-1 in diabetes mellitus?
Blimp-1 inhibits Th9 cell differentiation and attenuates diabetic coronary heart disease. PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing CD25 (IL2RA). Hypomethylation of PRDM1 is associated with recurrent pregnancy loss.
What is the role of blimp1/prdm1 in primary effusion lymphoma?
The PRDM1 expression appeared to play an essential role in Warthin tumour pathogenesis. Blimp-1 regulates the transcription of CS1 gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients. Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma.
What is the role of Blimp1 in lung cancer?
Blimp1 is a mediator of Ras/Raf/AP-1 signaling that promotes cell migration, and is repressed by LOX-PP in lung cancer. B-cell receptor stimulation induced ERK1/2 activation and upregulation of BLIMP1 mRNA expression in B cells
Is Blimp-1 a cytotoxic effector in CD8 T cells?
The PAX5-OCT4-PRDM1 proteins form a core transcriptional network that activates germline and represses somatic programmes during human germ cell differentiation. These findings suggest that Blimp-1 initiates cytotoxic effector function and that Hobit maintains cytotoxicity in a deployment-ready modus in tissue-resident memory CD8 T cells.
