What is solvent detergent plasma?
What is solvent detergent plasma?
Solvent detergent plasma is a form of blood plasma made from plasma collected from many people which is then processed with solvents as a form of virus processing, to try to get rid of viruses.
What is solvent detergent treated?
The solvent/detergent treatment is an established virus inactivation technology that has been industrially applied for manufacturing plasma derived medicinal products for almost 30 years.
What is Octaplas?
Octaplas is a form of solvent-detergent, virus-inactivated FFP, prepared by Octapharma. It uses a solvent-detergent treatment of 1% trinitrobutyl phosphate and 1% Triton X-100 for four hours at 30°C.
What is methylene blue treated FFP?
Methylene blue-treated fresh-frozen plasma (MB-FFP) is mainly used in Europe. The advantage of the methylene blue system is that units can be treated individually. The combined action of methylene blue and illumination is a photodynamic process preventing viral RNA and DNA replication.
How do detergents inactivate viruses?
Solvent/detergent (S/D) inactivation The detergents used in this method interrupt the interactions between the molecules in the virus’s lipid coating. Most enveloped viruses cannot exist without their lipid coating so are destroyed when exposed to these detergents.
How does low pH inactivate virus?
Low pH Method for Viral Inactivation. Low pH viral inactivation of biotherapeutic products is known to be influenced by pH, time, temperature, protein content and solute or buffer content. Many viruses are irreversibly denatured and effectively destroyed at pH 5.0–5.5.
What is cryoprecipitate used for?
Cryo is used to prevent or control bleeding in people whose own blood does not clot properly. This includes patients with serious but rare hereditary conditions such as Hemophilia A (who lack factor VIII) and von Willebrand disease (who lack von Willebrand factor).
When should Octaplas be used?
Octaplas is a solvent / detergent (S/D) treated, pooled human plasma indicated for:
- Replacement of multiple coagulation factors in patients with acquired deficiencies. due to liver disease. undergoing cardiac surgery and liver transplant.
- Plasma exchange in patients with thrombotic thrombocytopenic purpura (TTP)
Why is plasma treated with methylene blue?
Methylene blue (MB) was the first method developed for pathogen inactivation of a labile blood component that was introduced in 1991. MB and light (MBL) inactivates most lipid-enveloped viruses and those non-enveloped are, in general, resistant.
What are blood transfusions?
A blood transfusion is a common, safe medical procedure in which healthy blood is given to you through an intravenous (IV) line that has been inserted in one of your blood vessels. Your blood carries oxygen and nutrients to all parts of your body.
How does one inactivate a virus?
The inactivation of virus contaminants can be achieved by subjecting the bioprocess fluid to conditions that denature the virus protein but not the active ingredient. In the production of biologic therapies, the two most commonly employed inactivation methods are the use of low pH or addition of detergents.
Can you deactivate a virus?
Many viruses contain lipid or protein coats that can be inactivated by chemical alteration. Viral inactivation is different from viral removal because, in the former process, the surface chemistry of the virus is altered and in many cases the (now non-infective) viral particles remain in the final product.
