What is the meaning of cardiotoxic?
What is the meaning of cardiotoxic?
Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage. The heart becomes weaker and is not as efficient in pumping and therefore circulating blood.
What are cardiotoxic drugs?
Drug-induced cardiotoxicity, commonly in the form of cardiac muscle dysfunction that may progress to heart failure, represents a major adverse effect of some common traditional antineoplastic agents, e.g., anthracyclines, cyclophosphamide, 5 fluorouracil, taxanes, as well as newer agents such as biological monoclonal …
Which of the following is cardiotoxic?
Chemotherapy agents that can cause reversible cardiotoxicity are trastuzumab, bevacizumab, lapatinib, and sunitinib. These agents also may cause hypertension.
Is cardiotoxicity heart failure?
Heart failure is one of the most dramatic clinical expressions of cardiotoxicity, and it may occur acutely or appear years after treatment.
Why is cardiotoxicity important?
Cardiotoxicity is one of the most important adverse reactions of chemotherapy, leading to an important increase of morbidity and mortality (5,6). Cardiotoxicity can appear early or late in the course of the disease, and may vary from subclinical myocardial dysfunction to irreversible heart failure or even death (7).
How is cardiotoxicity diagnosed?
Standard current methods for detection of cardiotoxicity primarily involve serial measurement of the left ventricular ejection fraction (LVEF), a parameter that when reduced is a late manifestation in the cardiotoxic paradigm and when the possibility for reversibility declines.
Is paclitaxel cardiotoxic?
Paclitaxel has cardiotoxic effects. Careful monitoring of cardiac function during and after paclitaxel infusion is required in patients with high-risk features.
What is drug induced cardiomyopathy?
Drug-induced cardiomyopathy (CM) is a potentially reversible form of acquired CM and a common consequence of exposure to numerous medically prescribed drugs. It is particularly a common serious adverse side effect of anticancer and antiretroviral therapies.
What are signs of cardiotoxicity?
Symptoms of Cardiotoxicity
- Shortness of breath.
- Chest Pain.
- Heart palpitations.
- Fluid retention in the legs.
- Distention of the stomach.
- Dizziness.
Is pertuzumab a cardiotoxic?
The cardiotoxicity of trastuzumab, a HER2-targeting monoclonal antibody, is well established. However, the cardiotoxic effect of pertuzumab, another HER2-directed therapy, is less well documented.
Is carbo taxol cardiotoxic?
Is carboplatin a cardiotoxic?
Other cytostatics more frequently correlated with cardiotoxic side effects are taxanes (paclitaxel, docetaxel), alkylating agents (Carboplatin, Cisplatin, Cyclophosphamide), small molecule tyrosine kinase inhibitors (lapatinib, imatinib, sorafenib, sunitinib) and trastuzumab, a monoclonal antibody directed against the …
What is cardiotoxicity and what causes it?
Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage. The heart becomes weaker and is not as efficient in pumping and therefore circulating blood. Cardiotoxicity may be caused by chemotherapy treatment, complications from anorexia nervosa, adverse effects of heavy metals intake,…
How is cardiotoxicity diagnosed in subconical heart disease?
One of the ways to detect cardiotoxicity at early stages when there is a subconical dysfunction is by measuring changes in regional function of the heart using strain.
How is cardiotoxicity from anthracyclines defined?
The largest MUGA-based study to date defined cardiotoxicity from anthracyclines as a >10% fall in LVEF to <50%. 23 Subsequently, during the review of trastuzumab treatment trials, the Cardiac Review and Evaluation Committee 24 defined cardiotoxicity as an asymptomatic reduction in LVEF by ≥10% or a symptomatic reduction of ≥5% to <55% (Table 1).
What does “poisoning the heart” mean?
Having a damaging or poisoning effect on the heart. Denotes with deleterious effect on action of heart, due to poisoning of the cardiac muscle or of its conducting system. Want to thank TFD for its existence?
