What is the significance of globulin?

What is the significance of globulin?

Globulins are a group of proteins in your blood. They are made in your liver by your immune system. Globulins play an important role in liver function, blood clotting, and fighting infection. There are four main types of globulins.

What is a good range for globulin?

The normal range of globulin is around 2.0-3.9 g/dL or 20-39 g/L. Some lab-to-lab variability occurs due to differences in equipment, techniques, and chemicals used. Globulin in the normal range usually implies a normal balance of carrier proteins, enzymes, and antibodies that are needed for many biological processes.

Is High globulin bad?

An increase in gamma globulin proteins can indicate infection, chronic inflammation, and in severe cases, a type of cancer called multiple myeloma.

What does high alpha 1 globulin mean?

High alpha-1 globulin: Infection; inflammation. High alpha-2 globulin: Inflammation; kidney disease. High beta globulin: Very high cholesterol; low iron (iron-deficiency anemia) High gamma globulin: Inflammation; infection; liver disease; some forms of cancer.

What does it mean if your albumin globulin ratio is high?

High A/G ratio: This can be a sign of disease in your liver, kidney, or intestines. It’s also linked to low thyroid activity and leukemia. If your doctor feels any of your levels are too high or low, you may need to have more precise blood or urine tests.

What is a high albumin globulin ratio?

What causes low globulin?

Low Globulin Levels. Renal disease, hepatic dysfunction, celiac disease, inflammatory bowel disease (IBD) and acute hemolytic anemia can cause the globulin levels to drop. This is also a sign that proteins taken in by the digestive system are not being broken down or absorbed properly.

What is the difference between albumin and globulin?

The main difference between albumin and globulin is that albumin is the key protein in the blood, which regulates the osmotic pressure of blood whereas globulin is the second abundant type of proteins in the blood and is important in liver function, blood clotting, and fighting infections.

What does it mean when your alpha-2 globulin is high?

Increased alpha-2 globulin proteins may indicate a: Acute inflammation. Chronic inflammation.

Is a 2.4 Ag ratio high?

In general, an albumin/globulin ratio between 1.1 and 2.5 is considered normal, although this can vary depending on the laboratory performing the test [4]. Your blood usually contains a little more albumin than globulin, which is why a normal ratio is slightly higher than 1 [1].

What is the clinical significance of Gc-globulin?

Background: Gc-globulin (vitamin D–binding protein) appears to have important functions in addition to its role as a carrier of vitamin D. Approach: We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin.

What is the role of Gc-globulin in procoagulant actin clearance?

Clinical studies and animal models have shown that Gc-globulin has an important role in the clearance of procoagulant actin from the circulation after its release during cell necrosis and tissue injury.

What does an increase in gamma globulin levels indicate?

An increase in gamma globulin proteins can indicate infection, chronic inflammation, and in severe cases, a type of cancer called multiple myeloma . While these tests can help a doctor make a diagnosis, a doctor will also use other tests and evaluations to diagnose a specific condition or illness.

What does globulin mean in blood tests?

Globulin proteins are important to liver and kidney function. A total protein test is a good indication of how the liver is working. Low total protein levels can be a sign of liver disease. The second type of globulin test is serum protein electrophoresis. This test measures gamma globulin and other trace proteins in the blood.