Can MGUS cause breast cancer?

Can MGUS cause breast cancer?

Patients with MGUS have a higher risk of developing nonhematological malignancies, including nonmelanoma skin cancer, endocrine cancer, breast cancer, renal and urinary cancer, respiratory cancer, male reproductive system cancer and gastrointestinal cancer.

Is there a link between multiple myeloma and breast cancer?

Women with breast cancer also were at higher risk for multiple myeloma (MM) and acute lymphoblastic leukemia/lymphocytic lymphoma (ALL/LL) compared with the background population, reported Marie Joelle Jabagi, PharmD, MPH, of the University of Paris Sud, France, and her colleagues.

Can multiple myeloma spread to the breast?

Breast involvement by Multiple Myeloma (MM) is rare and the diagnosis is difficult because of the unspecificity of clinical and radiological features. The authors report a case of breast masses that were the first symptoms of recurrent MM after complete remission and bone marrow transplantation.

What is the life expectancy of someone with MGUS?

Data from the Mayo Clinic showed that the median survival of MGUS patients was 8.1 years compared to 11.8 in the comparable US population.

Is MGUS a serious condition?

MGUS usually causes no problems. But sometimes it can progress to more-serious diseases, including some forms of blood cancer. If you have high amounts of this protein in your blood, it’s important to have regular checkups so that you can get earlier treatment if it does progress.

What is high-risk MGUS?

People who have high-risk MGUS have any of the following features: The M-protein level is more than 15 g/L. The type of M-protein is IgA or IgM. The free light chain ratio is abnormal.

Can breast cancer cause lytic lesions?

Lytic lesions were attributed to relapse of breast cancer, and cardiac failure attributed to prior trastuzumab therapy.

Is multiple myeloma a metastatic cancer?

Metastasis and multiple myeloma are common malignant disease involving bone marrow. Metastasis is most common, and appeared in various form of lytic or sclerotic bone lesions. The incidence of multiple myeloma is increasing in recent years [1].

Is MGUS serious?

Is MGUS fatal?

This protein is called monoclonal protein, or M protein. It’s made by white blood cells called plasma cells in the body’s bone marrow. Usually, MGUS isn’t a cause for concern and has no adverse health effects.