Can MS cause calcification?
Can MS cause calcification?
Idiopathic calcification of the basal ganglia is a rare neurodegenerative disorder of unknown cause that is characterized by sporadic or familial brain calcification. Concurrence of multiple sclerosis (MS) and idiopathic basal ganglia calcification (Fahr’s disease) is very rare event.
Do all MS patients have lesions on the brain?
In multiple sclerosis (MS), the body mistakenly attacks the protective layer around the nerves in the brain and spinal cord (also known as myelin). These damaged areas are called plaques or lesions. Everyone with MS will get lesions with varying severity.
Where do MS lesions start?
MS can cause a wide variety of neurologic symptoms since it can affect numerous areas of the brain, optic nerve, and spinal cord (Figure 3). Characteristic lesions are located in the periventricular and juxtacortical regions, in addition to the brainstem, cerebellum, spinal cord, and optic nerve.
What does active MS lesions mean?
An MRI scan can differentiate between active and non-active lesions. Active lesions show up in the scan as white patches when a contrast fluid containing gadolinium is injected. If the lesion does not light up, then it is likely to be an older lesion, and more than 3 months old.
Is periventricular lesion a hallmark of multiple sclerosis (MS)?
The presence of periventricular lesion (PVL) has been considered a hallmark of multiple sclerosis (MS) and was included in the 2010 revised McDonald MS criteria of “dissemination in space” [1] based on observation of Swanton et al.
What are periventricular lesions (PVL) on MRI?
The presence of periventricular lesions (PVL) on MRI scans is part of the revised McDonald multiple sclerosis (MS) diagnostic criteria. However, PVL can be found in other neurological diseases including stroke and migraine.
What are calcifications of the periventricular area?
Calcifications are usually seen in the periventricular area, brain parenchyma or basal ganglia. Periventricular calcifications are usually described as thick and chunky in appearance whereas calcifications in the basal ganglia are usually faint and punctate (Fig. 4a).
What is the prevalence of periventricular plaques?
Periventricular plaques were found in 82.2% of cases. Observation and computerized morphology showed that the early stage of the periventricular plaque is the formation of a lesion around a subependymal vein and that adjacent lesions later coalesce.
