How do you store vasopressin?

How do you store vasopressin?

Store between 2°C and 8°C (36°F and 46°F). Do not freeze. Vials may be held up to 12 months upon removal from refrigeration to room temperature storage conditions (20°C to 25°C [68°F to 77°F], USP Controlled Room Temperature), anytime within the labeled shelf life.

How long does vasopressin last in the fridge?

Conclusions: Vasopressin diluted to 0.4 units/mL and 1 units/mL with 0.9% sodium chloride injection in polyvinyl chloride bags and syringes was stable up to 90 days at room temperature and under refrigeration.

How do you mix vasopressin?

Patients who are not fluid restricted: Prepare concentration of 0.1 units/mL by mixing 50 units (2.5 mL) of vasopressin injection with 500 mL of diluent. Patients who are fluid restricted: Prepare concentration of 1 unit/mL by mixing 100 units (5 mL) of vasopressin injection with 100 mL of diluent.

How is vasopressin metabolized?

It has a half-life of 10–35 min, being metabolized by vasopressinases which are found in the liver and kidney. Vasopressin acts on V1, V2, V3, and oxytocin-type receptors (OTR). V1 receptors are found on vascular smooth muscle of the systemic, splanchnic, renal, and coronary circulations.

How do vasopressin receptor antagonists work?

Vasopressin antagonists are drugs that bind to vasopressin receptors (V1A, V1B and V2) and block the action of vasopressin (antidiuretic hormone, ADH), which is a hormone released by the pituitary gland. Vasopressin causes vasoconstriction and increases reabsorption of water by the kidneys.

Can you give vasopressin IV push?

Routes. Vasopressin may be given IV/IO or by endotracheal tube.

Can vasopressin be given IV push?

40 units of vasopressin IV/IO push may be given to replace the first or second dose of epinephrine, and at this time, there is insufficient evidence for recommendation of a specific dose per the endotracheal tube. In the ACLS pulseless arrest algorithm, vasopressin may replace the first or second dose of epinephrine.

What is norepinephrine used to treat?

Norepinephrine is similar to adrenaline. It is used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures. Norepinephrine is often used during CPR (cardio-pulmonary resuscitation).

What is the composition of a vasostrict solution?

Vasostrict is a sterile, aqueous solution of synthetic arginine vasopressin for intravenous administration. The 1 mL solution contains vasopressin 20 units/mL, chlorobutanol, NF 0.5% as a preservative, and Water for Injection, USP adjusted with acetic acid to pH 3.4 – 3.6.

How many vials are in a carton of vasostrict?

Vasostrict (vasopressin injection, USP)is supplied in vials as follows: A carton of 25 multi-dose vials each containing vasopressin1 mL at 20 units/mL. Store between 2°C and 8°C (36°F and 46°F). Do not freeze.

How many units are in a vasostrict injection?

Vasostrict® (vasopressin injection, USP) is a clear, practically colorless solution for intravenous administration available as 20 units/mL in a single dose vial and 200 units/10 mL (20 units/mL

Does vasopressin need to be refrigerated?

Each vial contains vasopressin 100 mL at 60 units/100 mL (0.6 units/mL). Store between 2°C and 8°C (36°F and 46°F). Do not freeze. Vials may be held up to 12 months upon removal from refrigeration to room temperature storage conditions (20°C to 25°C [68°F to 77°F], USP Controlled Room Temperature), anytime within the labeled shelf life.