How is glargine insulin calculated?
How is glargine insulin calculated?
Our dose calculation formula is expressed as: [optimal daily dose of insulin glargine at 24 weeks] = starting dose (0.15×weight) + incremental dose (baseline HbA1c – target HbA1c+2).
What type of insulin is glargine?
Insulin glargine belongs to a drug class called long-acting insulins. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Insulin glargine works by controlling how sugar is used and stored in your body.
What is insulin glargine made of?
Insulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism.
How many units of insulin are in glargine?
The disposable, prefilled pen of Lantus is called SoloStar. Each pen contains 3 mL of solution. There are 100 units of insulin glargine in each mL. That adds up to a total of 300 units of insulin per Lantus SoloStar pen.
What does insulin glargine do?
Insulin glargine is a long-acting, manmade version of human insulin. Insulin glargine products work by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar.
What kind of insulin is lantus Solostar?
Lantus (insulin glargine) is a man-made form of a hormone (insulin) that is produced in the body. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin glargine is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours.
What is insulin glargine action?
Insulin glargine works the same way as natural human insulin, but it’s action lasts longer. It helps diabetic patients regulate glucose or sugar in the body. Insulin glargine works by promoting movement of sugar from blood into body tissues and also stops sugar production in liver.
How is insulin metabolised?
Thus, by increasing GLUT-4’s presence on the plasma membrane, insulin allows for glucose entry into skeletal muscle cells for metabolism into glycogen. In the liver, insulin affects glycogen metabolism by stimulation of glycogen synthesis.
How many mL is a SoloSTAR pen?
Each cartridge contains 3 ml of solution for injection, equivalent to 300 units. *Insulin glargine is produced by recombinant DNA technology in Escherichia coli.
How many units is a SoloSTAR pen?
The Lantus® SoloSTAR® pen is a prefilled, disposable insulin pen that contains 300 Units of insulin glargine. The pen body consists of a rubber seal at the tip, an insulin reservoir, a dose window, the dosage selector, and the injection button.
What is insulin glargine?
Insulin Glargine is a recombinant human insulin analog with long-acting, blood glucose -lowering activity. Insulin glargine, like regular types of human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose.
What is the mechanism of action of glargine?
Mechanism of action. Insulin glargine binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor.
Is glargine or NPH better for type 2 diabetes?
The long-acting insulin class, which includes insulin glargine, do not appear much better than neutral protamine Hagedorn (NPH) insulin, but do have a greater cost, making them, as of 2010, not cost effective for the treatment of type 2 diabetes.
Is insulin glargine the same as insulin Lantus?
Insulin glargine, marketed under the names Lantus among others, is a long-acting insulin, used in the treatment of type I and type II diabetes. It is not typically the recommended long acting insulin in the United Kingdom. It is used once a day as a injection just under the skin.
