Is autologous stem cell transplantation still relevant for multiple myeloma?
Is autologous stem cell transplantation still relevant for multiple myeloma?
More than 30 years after its introduction, autologous stem cell transplantation (ASCT) remains the standard of care for young patients with newly diagnosed multiple myeloma.
Can a bone marrow transplant help multiple myeloma?
A stem cell transplant, also called a bone marrow transplant, can be an effective part of treatment for multiple myeloma. Hematopoietic stem cells reside in the bone marrow. They can produce all types of blood cells, including white blood cells, red blood cells, and platelets.
How long can you live after multiple myeloma stem cell transplant?
Records covering a total of 4,329 patients, with a median age at diagnosis of 59, were reviewed. Across the entire group, these people were followed for a median of 10.5 years, and a median overall survival of 6.9 years.
Is stem cell transplant curative for multiple myeloma?
Only allogeneic hematopoietic stem cell transplantation is potentially curative, because of an immunologic graft-versus-myeloma effect. High transplant-related mortality associated with allogeneic stem cell transplantation is currentlythe major limitation to wider use of this modality.
Is autologous stem cell transplant safe?
Autologous stem cell transplantation is safe and feasible in elderly patients with multiple myeloma. Bone Marrow Transplant.
What happens if autologous stem cell transplant fails?
The graft may fail to grow in the patient—resulting in bone marrow failure—with the absence of red blood cells, white blood cells and platelet production. This results in infection, anemia and bleeding.
Are autologous transplant painful?
You may also have aches and pain from the medication. Sometimes another drug may be used during the blood collection to help the stem cells move from your bone marrow into to your bloodstream, making them easier to collect.
What is the best treatment for multiple myeloma?
Treatment for multiple myeloma includes drugs that modulate the immune system, chemotherapy drugs, radiation therapy, stem cell transplants and, in some patients, surgery.
How effective is Revlimid for multiple myeloma?
Multiple myeloma. Revlimid was more effective than placebo (a dummy treatment) in two main studies in 1,074 patients with newly diagnosed multiple myeloma and who had had stem cell transplantation. The main measure of effectiveness was how long patients lived without their cancer getting worse.
How does Revlimid treat multiple myeloma?
Revlimid, also known as lenalidomide, is an oral cancer drug that is used for the treatment of multiple myeloma. It is part of a class of drugs called immunomodulatory drugs (IMiDs), which work against cancer cells partly by supporting the function of the immune system. Revlimid is manufactured by Celgene.
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