Is cisplatin used for lung cancer?

Is cisplatin used for lung cancer?

Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30 years in a wide variety of cancers with varying degrees of success. In particular, cisplatin has been used to treat late stage non-small cell lung cancer (NSCLC) as the standard of care.

Is cisplatin used to treat lymphoma?

Administered intravenously to humans, cisplatin is used as first-line chemotherapy treatment for patients diagnosed with various types of malignancies, such as leukemia, lymphomas, breast, testicular, ovarian, head and neck, and cervical cancers, and sarcomas.

Which is better carboplatin or cisplatin?

Meta-analyses of palliative chemotherapy indicate consistent survival advantages with cisplatin-based therapy over carboplatin; however, the relative advantage is small. Cisplatin carries a higher toxicity profile, including nausea, vomiting, neuropathy, renal insufficiency, and alopecia in comparison to carboplatin.

Is cisplatin used in cancer chemotherapy?

Among many chemotherapy drugs that are widely used for cancer, Cisplatin is one of the most compelling ones. It was the first FDA-approved platinum compound for cancer treatment in 1978 (Kelland, 2007).

Can Stage 3 Nsclc be cured?

Currently, there is no cure for stage 3 lung cancers, but treatment can often help prolong life and relieve symptoms. In some cases, a person with stage 3 lung cancer may survive another 5 years or longer.

What is the most common side effect of cisplatin?

The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy. Anti-nausea medication is given before the infusion, and a prescription is also given for use after.

What is cisplatin platinum?

Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to DNA and inhibiting its replication. Cisplatin was discovered in 1845 and licensed for medical use in 1978 and 1979. It is on the World Health Organization’s List of Essential Medicines.

Is oxaliplatin the same as cisplatin?

Oxaliplatin has been shown to be at least as effective as cisplatin for this disease, but with less toxicity and a better tolerability profile, especially for older patients.

Is there an alternative to cisplatin?

In the case of absolute interdiction of cisplatin, several alternative regimens incorporating carboplatin, 5-fluorouracil, cetuximab, and docetaxel are available.

How long does it take for cisplatin to leave your body?

The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months.

How long does it take to recover from a lung lobectomy?

Your Recovery It is common to feel tired for 6 to 8 weeks after surgery. Your chest may hurt and be swollen for up to 6 weeks. It may ache or feel stiff for up to 3 months. For up to 3 months, you may also feel tightness, itching, numbness, or tingling around the cut (incision) the doctor made.

Is Nsclc curable?

Treating stage 0 NSCLC Because stage 0 NSCLC is limited to the lining layer of the airways and has not invaded deeper into the lung tissue or other areas, it is usually curable by surgery alone. No chemotherapy or radiation therapy is needed.

Is there a new cisplatin resistance mechanism in NSCLC?

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition These results describe a new cisplatin resistance mechanism in NSCLC based on a metabolic reprogramming that is therapeutically exploitable through PGC-1α downregulation or OXPHOS inhibitors.

Is there metabolic reprogramming of non-small cell lung cancer in response to cisplatin?

In this study, we first described the metabolic reprogramming of Non-Small Cell Lung Cancer (NSCLC) in response to cisplatin treatment. Methods: Cisplatin-resistant versions of the A549, H1299, and H460 cell lines were generated by continuous drug exposure.

Is cisplatin + etoposide curable in metastatic lung cancer?

If the disease is metastatic, cisplatin + etoposide may not be curative, but may still prolong life and relieve certain symptoms. Durvalumab (Imfinzi) may be given to certain patients with Stage 3 unresectable non-small cell lung cancer (NSCLC) after they complete chemotherapy plus radiation.

Is cisplatin resistance associated with G2/M cell cycle arrest in non-small cell cancer?

Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest PLoS One. 2017 Jul 26;12(7):e0181081.doi: 10.1371/journal.pone.0181081. eCollection 2017. Authors