What are desired characteristics of dendrimers?

What are desired characteristics of dendrimers?

In addition, the easy-to-control characteristics of dendrimers (namely: size, shape, liposome blockage in dendrimeric structures, branch length, surface functionality and synthesis of targeted dendritic scaffolds) makes these systems ideal carriers in many applications.

What are dendrimers made of?

4.2 Dendrimers. Dendrimers are globular, monodisperse macromolecules with three-dimensional polymeric architectures, made from synthetic polymers consisting of a core and several layers with active terminal groups.

How dendrimers are used in nano material synthesis?

Dendrimers used for enhancing solubility Dendrimer-based carriers offer the opportunity to enhance the oral bioavailability of problematic drugs. Thus, dendrimer nano carriers offer the potential to enhance the bioavailability of drugs that are poorly soluble and/or substrates for efflux transporters [70,71].

How are dendrimers formed?

Dendrimers are constructed by the successive addition of layers to the branching groups. The synthesis of dendrimers involves a core molecule with branching groups to which other branching molecules are added (see figure below) in layers. Each new layer is called a generation.

Which polymer is incorporated into dendrimers?

Poly(ether imine) dendrimers are a new class of biocompatible dendrimers. Krishna et al. developed these types of dendrimers by combing the properties of two linear polymers, PEG and poly(ethylene imine), with the dendrimers. They reported a rapid method for synthesis of the poly(ether imine) dendrimers.

What is a nanocomposite material?

Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix.

What is polymer explain?

A polymer is any of a class of natural or synthetic substances composed of very large molecules, called macromolecules, which are multiples of simpler chemical units called monomers. Polymers make up many of the materials in living organisms and are the basis of many minerals and man-made materials.

What are polymeric nanoparticles?

Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases.

How are dendrimers used?

Dendrimers can be used as dendritic boxes and unimolecular micelles (dendrimer-drug networks) for the incorporation of hydrophobic/hydrophilic molecules by host guest interactions inside their empty cavities (nanoscale containers) present around core.

What is a dendrimer used for?

Dendrimers can be used as dendritic boxes and unimolecular micelles (dendrimer-drug networks) for the incorporation of hydrophobic/hydrophilic molecules by host guest interactions inside their empty cavities (nanoscale containers) present around core. [78,79] Jansen et al.

What are Pamam dendrimers?

PAMAM dendrimers are a family of highly branched and mono-disperse synthetic macromolecules with well-defined structures and compositions. Synthesis of these nanocarriers can be carried out through the divergent route.

What are the biological properties of dendrimers?

Their three traditional macromolecular architectural classes are broadly recognized to generate rather polydisperse products of different molecular weights. A variety of dendrimers exist, and each has biological properties such as polyvalency, self-assembling, electrostatic interactions, chemical stability, low cytotoxicity, and solubility.

Why are dendrimers used as a delivery vehicle in biotechnology?

Therefore, dendrimers have become an ideal delivery vehicle candidate for explicit study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, internalization, blood plasma retention time, biodistribution, and filtration [ 19] (Figure 1 ).

How do dendrimers compare to other nanoscale synthetic structures?

When comparing dendrimers with other nanoscale synthetic structures (e.g., traditional polymers, buck balls, or carbon nanotubes), these are either highly non-defined or have limited structural diversity.

How to synthesize polyamidoamine if dendrimers?

Approaches for the synthesis if dendrimers. (A) Divergent approach: synthesis of radially symmetric polyamidoamine (PAMAM)dendrimers using ammonia as the trivalent core; the generations are added at each synthetic cycle (two steps), leading to an exponential increase in the number of surface functional groups [37].

https://www.youtube.com/watch?v=b-X3rudiqUs