What does CD30 positive mean?
What does CD30 positive mean?
CD30-positive cells characterize lymphomatoid papulosis and anaplastic large cell lymphoma but can also be found in nonneoplastic skin disorders. Purportedly, CD30 is useful in the differential diagnosis between insect bites and lymphomatoid papulosis.
What is CD30 and CD15?
Coexpression of CD30 and CD15 is typically associated with classic Hodgkin’s lymphoma (HL). Peripheral T-cell lymphomas (PTCLs) can often display histologic features that simulate classic HL. However, reports of PTCLs coexpressing both CD30 and CD15 have been infrequently described.
What does CD30 stand for?
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
Which cells express CD30?
3 CD30. CD30 is a transmembrane protein that is expressed in normal activated T cells, B cells, NK cells, and malignant cells.
What does CD30 negative mean?
Testing for CD30 protein Depending on your T-cell lymphoma diagnosis, your doctor may order a test to find out how much CD30 is on your cancer cells. In some cases, the test result may be negative, meaning that your doctor may conclude that CD30 protein was not found.
What is CD30-positive T-cell lymphoma?
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma.
What is CD15 a marker for?
The glycan determinant CD15 (also known as Lewis x, or Le(x)) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells.
What does CD15 positive mean?
CD15 is present on almost all Reed–Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies. Hodgkin lymphoma. The presence of these cells is diagnostic of Hodgkin’s lymphoma.
Where is CD30 found?
A protein found on some T cells and B cells (two types of white blood cells). It is a receptor for a protein called tumor necrosis factor, which is involved in cell growth and cell survival. The CD30 protein may be found in higher than normal amounts on some types of cancer cells, including lymphoma cells.
What is CD30 antibody?
CD30 has been identified as a marker on Reed–Sternberg cells in Hodgkin lymphoma and cells in other specific types of lymphoma. CD30 monoclonal antibodies may be used to treat Hodgkin’s lymphoma or anaplastic large cell lymphoma.
What is CD30 positive lymphoma?
Primary cutaneous CD30-positive large cell lymphoma (CD30+ PCLCL) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that can present in a variety of ways. We report a patient with a three-month history of an enlarging, exophytic mass with two smaller satellite lesions on the left forearm.
How common is cutaneous T-cell lymphoma?
CTCL is a rare form of T-cell lymphoma. There are about 3,000 new cases of CTCL in the U.S. each year, and about 16,000 – 20,000 Americans have mycosis fungoides.
