What does high Hydroxyindoleacetic acid mean?

What does high Hydroxyindoleacetic acid mean?

Higher levels of 5-HIAA may mean you have: Carcinoid tumors. Noncarcinoid tumors. Cystic fibrosis.

What is HIAA urine test for?

This test measures the level of 5-HIAA in the urine. It is often done to detect certain tumors in the digestive tract (carcinoid tumors) and to track a person’s condition. The urine test may also be used to diagnose a disorder called systemic mastocytosis and some tumors of the hormone.

What could cause a false positive result in a urine 5-HIAA test?

False-positive 24-hour urine 5-HIAA results may be induced by the ingestion of tryptophan/serotonin-rich foods (pineapple, banana, kiwi, plum, tomato, avocado, walnut, eggplant, hickory nut, etc.), and certain medications and supplements such as acetaminophen, nicotine, and caffeine (5,6).

What disease may be associated with decreased 5-HIAA levels?

Diseases or disorders that display lower than normal urinary 5-hydroxy indoleacetic acid levels include obsessive-compulsive disorder, aromatic L-amino acid decarboxylation deficiency, sepiapterin reductase deficiency, and multiple sclerosis.

What can you not eat before a 24-hour urine test?

Preparing for the Collection To the best extent possible, avoid using vitamins, coffee, alcoholic beverages, salt and vanilla-containing foods for at least 24 hours before you start collecting the 24-hour urine and during the entire collection period.

What would high levels of 5-HIAA indicate?

24-hour urine 5-HIAA test With elevated values, levels greater than 25 mg/24 h or greater than 131 µmol/day indicate large carcinoid tumors, especially when in ileal, biliary, pancreatic, or duodenal tumors.

What does a low 5-HIAA mean?

24-hour urine 5-HIAA test With low values, levels less than 2 mg/24 h are found in depressive illness, Hartnup disease, mastocytosis, phenylketonuria, renal disease, and related small intestine resection (related to a decrease in enterochromaffin-producing cells).

How accurate is 5-HIAA urine test?

Urine 5-HIAA has been shown to have a sensitivity of 73% and specificity of 100% for diagnosing well-differentiated functional gastroenterohepatic neuroendocrine tumors. Compared with patients having normal urinary 5-HIAA levels, patients with elevated levels, whether symptomatic or not, tend to have poorer prognosis.

Why do you flush the first urine in a 24-hour urine test?

Don’t save the urine from your first time urinating. Flush this first specimen, but note the time. This is the start time of the 24-hour collection. All urine, after the first flushed specimen, must be saved, stored, and kept cold.

Why is the first voided urine discarded in a 24-hour urine collection?

Urine values vary considerably during a 24-hour period, and most test methods are based on normal values for first morning samples. The first urine voided in the morning is preferred because it has a more uniform volume and concentration and a lower pH, which helps preserve the formed elements.

What is 5HIAA (5-hydroxyindoleacetic acid)?

5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues.

What is (5-hydroxyindol-3-yl)acetic acid?

(5-hydroxyindol-3-yl)acetic acid is a member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5. It has a role as a drug metabolite, a human metabolite and a mouse metabolite. It is a conjugate acid of a (5-hydroxyindol-3-yl)acetate.

Is 5-hydroxyindoleacetic acid a useful measure of serotonin turnover?

The concentration of 5-hydroxyindoleacetic acid (5-HIAA) in lumbar spinal fluid (CSF) is a commonly used estimate of serotonin turnover in man. Valid comparisons between controls and psychiatric patients using this estimate necessitates sensitive and precise analytical methods and attention to factors such as age, body height and drug treatment.

Is 5-hydroxyindoleacetic acid a major metabolite of 5-HT metabolism?

Low concentrations of 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT metabolism, have been reported in the cerebrospinal fluid (CSF) of depressed patients ( Ågren, 1980; Åsberg et al., 1984 ), but not consistently replicated (reviewed by Gjerris, 1988 ).