What does l-methylfolate help with?
What does l-methylfolate help with?
L-methylfolate is a form of a B vitamin used to treat depression, megaloblastic anemia, and renal and hepatic impairment. L-methylfolate is available under the following different brand names: Deplin.
What does methylfolate do to the brain?
L-methylfolate is the only folate form that is capable of passing the blood-brain barrier, a border created by endothelial cells that allows nutrients into the brain. Once it crosses this barrier, l-methylfolate participates in the production of the neurotransmitters serotonin, dopamine, and norepinephrine.
How much l-methylfolate for depression?
A double-blind, placebo-controlled trial of l-methylfolate among folate-deficient patients with major depressive disorder showed that adding l-methylfolate 7.5 or 15 mg to standard therapy significantly improved clinical and social recovery.
Can l-Methylfolate be used as monotherapy?
L-methylfolate has mostly been studied as an add-on therapy in higher doses (15 mg daily) with an SSRI or other antidepressant, but may also be an effective monotherapy for patients with MDD.
Does methylfolate give you energy?
The MTHFR gene and L-methylfolate also play many other roles in our body. These include repairing DNA, aiding and supporting immune function, the body’s detoxification system, energy production, and more.
Can l-Methylfolate cause weight gain?
In addition, L-methylfolate augmentation did not lead to any significant differences in terms of gastrointestinal side effects, sedation, weight gain, and sexual dysfunctions.
Who needs to take Methylfolate?
L-methylfolate is a medical food for use in people who have conditions related to folate deficiency. L-methylfolate is also used in people with major depressive disorder who have folate deficiency, or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency.
Is 15mg Methylfolate too much?
Methylfolate can be helpful, but not generally in doses below 15 mg. Methylfolate seems to be especially helpful in obese patients.
Is 15 mg of L-Methylfolate too much?
What should I know about L-methylfolate before taking it?
First, if you are allergic to L-methylfolate, you should not take it. Further, you should tell your doctor if you have “seizures or epilepsy; a history of vitamin B12 deficiency or pernicious anemia; or a history of bipolar disorder (manic depression),” according to the U-M health library website.
How effective is L-methylfolate with SSRIs?
The response rates were 32.3% in the SSRI plus 15 mg L-methylfolate group compared with 14.6% in the SSRI plus placebo group. The number needed to treat to achieve response with the addition of 15 mg L-methylfolate to an SSRI was 6.
Does L-methylfolate cause agitation and mania?
Experts discuss the rationale and history of L-methylfolate use in patients, and then shares three cases that collectively suggest L-methylfolate may contribute to agitation and mania. L-methylfolate is commonly presented as a safe augmenting agent to patients with antidepressant non-response in unipolar depression with virtually no side effects.
