What does monoclonal pattern mean?
What does monoclonal pattern mean?
Monoclonal gammopathies are conditions in which abnormal proteins (antibodies) are found in the blood. These proteins are produced from a small number of plasma cells in the bone marrow. Plasma cells are a type of white blood cell.
What is the M spike in multiple myeloma?
immunoglobulin protein (M-spike) will appear as a large peak on the graph. that is being produced by the malignant plasma cells. The amount of protein produced may vary throughout the course of the disease, but the type generally will remain the same.
What does a monoclonal spike mean?
A monoclonal spike (M spike or paraprotein) on serum protein electrophoresis (SPEP) is a frequent finding in the general population and typically is pathognomonic of an asymptomatic, premalignant condition called monoclonal gammopathy of undetermined significance (MGUS).
What is monoclonal IGA?
Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein — known as monoclonal protein or M protein — is in your blood. This abnormal protein is formed within your bone marrow, the soft, blood-producing tissue that fills in the center of most of your bones.
What level of M spike is bad?
Bone marrow involvement by 10% or more MM cells, M spike equal or greater than 3 g/dL and an abnormal FLC ratio (equal or less than 0.125, or equal or exceeding 8) have been identified as risk factors for progression to active disease.
When should you suspect multiple myeloma?
Your Doctor May Suspect Multiple Myeloma Before You Do Low red blood cell counts, white blood cell counts, and platelet counts, which are common in multiple myeloma. High levels of calcium in your blood, called hypercalcemia. Abnormal proteins in your blood or urine.
How long can you live with monoclonal gammopathy?
Data from the Mayo Clinic showed that the median survival of MGUS patients was 8.1 years compared to 11.8 in the comparable US population.
Who is most likely to get multiple myeloma?
Myeloma occurs most commonly in people over 60. The average age at diagnosis is 70. Only 2% of cases occur in people under 40.
