What does negative HLA-B27 mean?

What does negative HLA-B27 mean?

Ask your healthcare provider what your test results mean for you. A negative result means you don’t have HLA-B27 in your blood. A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis.

What is HLA-B27 test positive?

A positive test means HLA-B27 is present. It suggests a greater-than-average risk for developing or having certain autoimmune disorders. An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue.

How common is HLA-B27 positive?

It is present in only 1.4-8% of the general population (higher in certain Native American groups and Scandinavians). Of patients with acute anterior uveitis, 50-60% may be HLA-B27 positive. Both racial background and national origin affect this rate of incidence.

Is HLA-B27 positive genetic?

AS can run in families, and the HLA-B27 gene can be inherited from another family member. If you have AS and tests show you carry the HLA-B27 gene then there is a 1 in 2 chance that you could pass on the gene to any children you have.

Can you get a false negative HLA-B27?

False-negative serological HLA-B27 typing results may be due to altered antigenic epitopes and can be detected by polymerase chain reaction. Br J Rheumatol.

Can you be negative HLA-B27 and still have ankylosing spondylitis?

Ankylosing spondylitis is strongly associated with the HLA-B27 gene. Testing is positive in over 90% of Caucasians. A negative test could be found in approximately 10% of Caucasian patients with the disease. The relationship is less strong in Blacks with only 50% of patients having a positive test.

Can you have psoriatic arthritis with negative HLA-B27?

Severe axial and peripheral involvement in HLA-B27-negative psoriatic arthritis (PsA) remains very rare.

What are the symptoms of HLA-B27?

joint pain. stiffness or swelling of your spine, neck, or chest. inflammation of your joints or urethra accompanied by skin lesions. recurring inflammation in your eye.

Can ankylosing spondylitis be seronegative?

Seronegative spondyloarthropathies are a family of joint disorders that classically include ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD) associated arthritis, reactive arthritis (formerly Reiter syndrome; ReA), and undifferentiated SpA.