What does the AVPR1A gene do?
What does the AVPR1A gene do?
The AVPR1A gene encodes arginine vasopressin receptor 1A (AVPR1A), a G-protein coupled receptor expressed in the brain, liver, kidney and vasculature. There is overwhelming evidence supporting the role of AVPR1A-mediated vasopressin signaling in behavioral modulation.
What does the V1a receptor do?
V1a receptor is the vascular smooth muscle cell receptor but is also found on a number of other cells, such as hepatocytes, cardiac myocytes, platelets, brain, and testis. The V1a receptors signal by activation of phospholipase C and elevation in intracellular calcium, which, in turn, stimulates vasoconstriction.
Where are V1a receptors?
The V1a receptor is originally found in the vascular smooth muscle and the V1b receptor in the anterior pituitary.
What do V1 and V2 receptors do?
The V1 receptor stimulates vascular smooth muscle contraction, resulting in the vasopressor response of AVP. The V2 receptors primarily act in the kidney to produce water retention (antidiuretic hormone), and the V3 receptors act in the central nervous system, and modulate corticotropin secretion.
What is V1b?
Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein that in humans is encoded by the AVPR1B (arginine vasopressin receptor 1B) gene. V1BR acts as a receptor for vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors.
What receptor does vasopressin bind to?
Vasopressin acts on V1, V2, V3, and oxytocin-type receptors (OTR). V1 receptors are found on vascular smooth muscle of the systemic, splanchnic, renal, and coronary circulations.
What receptors does vasopressin work?
What are the types of vasopressin receptor?
The biological effects of arginine vasopressin (AVP) are mediated by three receptor subtypes: the V1a and V1b receptors that activate phospholipases via Gq/11, and the V2 receptor that activates adenylyl cyclase by interacting with Gs.
What type of receptor does ADH use?
vasopressin receptors
ADH initiates its physiological actions by combining with a specific receptor. These are two major types of vasopressin receptors: V1 & V2. The V1 receptors are located on blood vessels and are responsible for the vasopressor action.
What type of receptors are V2 receptors?
Vasopressin receptor 2 (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor for vasopressin. AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the Gs type of G proteins, which stimulate adenylate cyclase.
Which of the following is vasopressin antagonist?
Vasopressin receptor antagonists (Vaptans) are a new group of nonpeptide drugs which have been used in various clinical conditions with limited success. Whereas conivaptan is to be administered intravenously, the other vaptans like tolvaptan, lixivaptan, and satavaptan are effective as oral medication.
