What is 5-MAPB (5-APB)?
These include such MDA -inspired substances as 5-APB, 6-APB and 5-EAPB, among others. 5-MAPB is the N-methylated form of 5-APB, analogously to how MDMA is the N-methylated form of MDA .
What is 5-APB (5-HT2A)?
5-APB is a triple reuptake inhibitor for norepinephrine, dopamine and serotonin as well as being an agonist for the 5-HT 2A and 5-HT 2B receptors. It has also been speculated that 5-APB acts as a releasing agent for the previously mentioned neurotransmitters .
What is the mechanism of action of 5-APB?
5-APB is a triple reuptake inhibitor for norepinephrine, dopamine and serotonin as well as being an agonist for the 5-HT 2A and 5-HT 2B receptors. It has also been speculated that 5-APB acts as a releasing agent for the previously mentioned neurotransmitters.
Is 5-APB a Class B drug?
On June 10, 2013 5-APB and a number of analogues were classified as Temporary Class Drugs in the UK following an ACMD recommendation. On November 28, 2013 the ACMD recommended that 5-APB and related benzofurans should become Class B, Schedule 1 substances.
What are the metabolites of 5-MAPB?
A study in rats indicated that the major metabolites of 5-MAPB are 5-APB and 3-carboxymethyl-4-hydroxymethamphetamine. 5-MAPB binds to the dopamine transporter in rat brain cells with a lower potency than cocaine. In silico data suggests that the primary action on dopamine is through reversal of the transporter to release dopamine.
Is 5-MAPB a Class B drug?
On March 5, 2014 the UK Home Office announced that 5-MAPB would be made a class B drug on 10 June 2014 alongside every other benzofuran entactogen and many structurally related drugs. Little formal knowledge exists on 5-MAPB. It does not form the alpha-methyldopamine metabolite that contributes to the neurotoxicity of MDMA or MDA.
What is 5-MAPB (1- (benzofuran-5-yl)-N-methylpropan-2-amine)?
5-MAPB ( 1- (benzofuran-5-yl)-N-methylpropan-2-amine) is an entactogenic designer drug similar to MDMA in its structure and effects. 5-MAPB is not listed itself in the CDSA but since it is structurally related to MDMA it may be considered illegal in Canada, although this has not been tested in court.