What is a KDEL motif?
What is a KDEL motif?
The KDEL sequence prevents a protein from being secreted from the endoplasmic reticulum (ER) and facilitates its return if it is accidentally exported. A protein with a functional KDEL motif will be retrieved from the Golgi apparatus by retrograde transport to the ER lumen.
What is a KDEL receptor?
The KDEL receptor is a Golgi/intermediate compartment-located integral membrane protein that carries out the retrieval of escaped ER proteins bearing a C-terminal KDEL sequence. This occurs throughout retrograde traffic mediated by COPI-coated transport carriers.
Is KDEL receptor involved in retrograde transport?
The KDEL receptor (KDELR) is a seven-transmembrane-domain protein involved in retrograde transport of protein chaperones from the Golgi complex to the endoplasmic reticulum. There is also massive recruitment of SEC31 to endoplasmic-reticulum exit sites.
What does KDEL stand for?
amino acid sequence
The KDEL stands for the amino acid sequence. It is a target peptide sequence that is found in plants and mammals. The main function of the KDEL sequence is to prevent a protein that is being secreted into the endoplasmic reticulum. The retrograde transport is associated with the KDEL sequence.
Is KDEL a protein?
The KDEL receptor is a seven-transmembrane-domain protein that was first described about 20 years ago. Its well-known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum.
Which proteins have Kdel sequence?
The surface GRP78 contains the KDEL sequence. On the cell surface, GRP78, PDI and Crt associate with other proteins and form complexes of different sizes. Surface Crt is found to be essential for the neurite formation when NG108-15 cells are induced to differentiate using dibutyryl cAMP.
What proteins have Kdel sequence?
Where do KDEL receptors release their cargo?
(A) The KDEL receptor acts in retrograde transport of secretory proteins. It interacts with soluble cargo proteins at the lower pH of the Golgi and it is directed to the ER via COPI vesicles. At the neutral pH of the ER, the receptor releases the cargo protein to the lumen.
What is KKXX signal?
KDEL and KKXX are short carboxy-terminal signals that play a crucial role for the localization in the endoplasmic reticulum (ER) of eukaryotic cells of many soluble proteins contained in the cisternal lumen and of type I transmembrane proteins, respectively (Munro and Pelham, 1987 ; Pelham, 1988 ; Nilsson et al.
Why does the KDEL receptor release the cargo in the ER lumen?
What is KKXX motif in Golgi apparatus?
This motif is exclusively cytoplasmic and interacts with the COPI protein complex to target the ER from the cis end of the Golgi apparatus by retrograde transport. The abbreviation KKXX is formed by the corresponding standard abbreviations for lysine (K) and any amino acid (X).
What does XKXX mean in biology?
KKXX (amino acid sequence) KKXX and for some proteins XKXX is a target peptide motif located in the C terminus in the amino acid structure of a protein responsible for retrieval of endoplasmic reticulum (ER) membrane proteins from the Golgi apparatus.
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