What is a toxic level of Depakote?
What is a toxic level of Depakote?
Its action is similar to that of other common anticonvulsants, such as phenytoin and carbamazepine. The therapeutic range for valproic acid is 50-100 mcg/mL. The toxic level is >100 mcg/mL.
What are the side effects of too much Depakote?
Check with your doctor right away if you are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness …
What can happen if you take too much valproic acid?
Taking too much valproic acid can lead to symptoms such as: feeling or being sick (nausea or vomiting) headaches, or feeling dizzy. muscle weakness.
How is valproic acid overdose treated?
Therapy for patients with valproate toxicity is mainly supportive and includes initial stabilization and resuscitation. Measures include maintenance of airway, breathing, and circulation. Establish early IV access as intravenous fluid administration for the patients presenting with hypotension.
How is Depakote toxicity treated?
The treatment of VPA toxicity is primarily supportive. Activated charcoal can be given early if the timing of overdose is known, especially if sustained release forms have been ingested sometimes several doses of activated charcoal can be helpful [9].
Is 2000 mg of Depakote too much?
The mean daily dose usually ranges between 1000 – 2000 mg valproate. Patients receiving daily doses higher than 45 mg/kg/day body weight should be carefully monitored. Continuation of treatment of manic episodes in bipolar disorder should be adapted individually using the lowest effective dose.
What happens if you overdose on Depakote?
Depakote has also been known to cause life-threatening damage to the pancreas. This problem can surface at any time, even after years of treatment. Call your doctor immediately if you develop any of the following warning signs: abdominal pain, loss of appetite, nausea, or vomiting.
What are the long term side effects of Depakote?
Depakote has been on the market for more than 30 years, and some side effects from long-term use are becoming apparent. More than six months is considered long-term use. The most well-known long-term side effect is the blood having more of a tendency to clot. Blood clots can lead to stroke or a heart attack.
What is the normal dose for Depakote?
Depakote ER is indicated for prophylaxis of migraine headaches in adults. The recommended starting dose is 500 mg once daily for 1 week, thereafter increasing to 1,000 mg once daily.
What is the toxic dose of Depakote?
The toxic level is greater than 150 µg/mL. The therapeutic range for valproic acid (free) is 6-22 µg/mL. The toxic level is greater than 50 µg/mL; above this threshold concentration, the binding sites on plasma albumin begin to become saturated.
