What is labetalol IV used for?

What is labetalol IV used for?

Labetalol injection is used to treat severe high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.

How is labetalol used in hypertensive emergency?

For hypertensive emergencies, reported dosing regimens for IV labetalol include a loading dose of 20 mg followed by 20 to 80 mg doses repeated every 10 minutes until desired BP is attained, or the loading dose can be administered followed by a 1 to 2 mg/min continuous infusion; all regimens have a total effective dose …

Is labetalol used in heart failure?

Because of its pharmacology, labetalol should not be used in patients with chronic obstructive lung disease, congestive heart failure, atrioventricular block, or bradycardia.

How much does labetalol iv lower heart rate?

The blood pressure reduction after the last dose of labetalol was 55/33 mm Hg. In pretreated patients and in those who had no medication for 24 hours prior to the intravenous labetalol, the response was similar. Heart rate decreased 10 beats per minute in the total population.

How is IV labetalol given?

Administration of continuous IV infusion: Dilute 100mg of labetalol in 30mL of sodium chloride 0.9% and delivery through a syringe driver. Infuse via a dedicated peripheral or central lumen. Do not attach to a two way infusion as an inadvertent bolus may be delivered. Commence infusion at 10 mL/hour (20mg/hour).

When do you give labetalol?

Take labetalol at a mealtime, or with something to eat. If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.

How do you do labetalol infusion?

What is end organ damage?

End organ damage usually refers to damage occurring in major organs fed by the circulatory system (heart, kidneys, brain, eyes) which can sustain damage due to uncontrolled hypertension, hypotension, or hypovolemia.

How does labetalol work in pre eclampsia?

Many preeclamptic women will not achieve blood pressure goals on this oral agent alone. Labetalol lowers blood pressure by blocking β- and α-adrenergic receptors. In addition, it can better preserve uteroplacental blood flow compared with other β-blockers. It has a rapid onset of action (2 h) compared with methyldopa.

Does labetalol cause pulmonary edema?

We conclude that the incidence of pulmonary edema in patients with severe preeclampsia who are treated with labetalol appears to be a result of an increase in third space fluid accumulation as a manifestation of the severity of their disease, not a direct effect of the drug on cardiac performance.

When do you give labetalol infusion?

Bolus injection If it is essential to reduce blood pressure quickly, as for example, in hypertensive encephalopathy, a dose of 50mg of labetalol hydrochloride should be given by intravenous injection over a period of at least one minute.

How do you calculate labetalol infusion?

The diluted solution should be administered at a rate of 2 mL/min to deliver 2 mg/min. Alternatively, 200 mg of labetalol hydrochloride injection is added to 250 mL of a commonly used intravenous fluid. The resultant solution will contain 200 mg of labetalol hydrochloride, approximately 2 mg/3 mL.

How much labetalol do you put in an infusion?

Intravenous infusion: A 1 mg/ml solution of labetalol should be used, i.e. the contents of two 20 ml ampoules (200 mg) diluted to 200 ml with the compatible I.V. infusion fluids indicated in section 6.6. The infusion rate will normally be about 160 mg/h but may be adjusted accorded to the response at the discretion of the physician.

How is a patient positioned for labetalol injections?

Patients should be placed in the supine position for bolus injections of labetalol to limit the risk of orthostatic hypotension. The initial dose is 20 mg, and repeat doses of 40 mg can be given at 10-minute intervals until the desired antihypertensive effect is achieved.

What are the possible complications of intravenous labetalol?

The most notable complications of intravenous labetalol include orthostatic hypotension (ablockade), myocardial depression (b-1 blockade), and bronchospasm (b-2 blockade). Orthostasis should not be a problem in the ICU, because patients are rarely ambulatory or in the upright position.

What is the role of labetalol in the treatment of hypertension?

It may be particularly effective in hypertension caused by excess circulating catecholamines, such as the hypertension that occurs in the early postoperative period. Because the antihypertensive actions of labetalol are not accompanied by an increase in cardiac output, the drug is particularly useful in the management of aortic dissection.