What is meperidine toxicity?

What is meperidine toxicity?

A meperidine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, blue-colored skin or lips, fainting, or coma.

Which drug effect is considered a major side effect of meperidine?

The major hazards of meperidine, as with other opioid analgesics, are respiratory depression and, to a lesser degree, circulatory depression, respiratory arrest, shock, and cardiac arrest. The most frequently observed adverse reactions included lightheadedness, dizziness, sedation, nausea, vomiting, and sweating.

Do you dilute meperidine?

Dilute oral solution in one-half glass of water prior to administration to avoid topical anesthesia of mucous membranes. When meperidine is given parenterally, the patient should be lying down.

How do you reverse Demerol?

While taking meperidine, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose.

What is meperidine hydrochloride IV?

Meperidine injection is used to relieve moderate to severe pain. It may also be used before and during surgery or other medical procedures. Meperidine injection is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the body senses pain.

Can you reverse Demerol?

What IV drugs need to be diluted?

The following medications require dilution: ranitidine, famotidine, pantoprazole, lorazepam, promethazine. In certain settings, the following drugs require dilution in order to give them IV push: Digoxin Immune FAB, ephedrine, phentolamine, phenylephrine, phenytoin, vitamin K, magnesium sulfate.

Can you reverse sedation?

Naloxone rapidly reverses sedation and respiratory depression due to previously administered narcotics, whereas flumazenil overturns the effects of midazolam on the central nervous system. Both agents are administered intravenously in repeated doses according to the patient’s response.

How do you reverse butorphanol?

Naloxone rapidly reverses respiratory depression produced by butorphanol.

Can meperidine be given IV?

Meperidine injection comes as a solution (liquid) to inject subcutaneously (just under the skin), intramuscularly (into a muscle), or intravenously (into a vein). It is usually injected subcutaneously or intramuscularly once every 3 to 4 hours as needed.