What is myofibroblastic proliferation?
What is myofibroblastic proliferation?
Background. Pseudosarcomatous myofibroblastic proliferation (PMP) is a rare disease entity of unknown etiology and pathogenesis. PMP is also known as an inflammatory pseudotumor (IPT) or inflammatory myofibroblastic tumor (IMT), and it is characterized by myofibroblast proliferation and inflammatory cell infiltration.
What is a myofibroblastic tumor?
An inflammatory myofibroblastic tumor (IMT) is an uncommon, usually benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age.
How do you treat inflammatory myofibroblastic tumors?
When necessary, surgical resection could be considered the preferred treatment for IMT, which can also be used to confirm this disease. The recurrence rate has been reported to range from 18% to 40%, and only precise removal of the tumor will avoid recurrence[11].
Is IMT a sarcoma?
A variant of IMT known as epithelioid inflammatory myofibroblastic sarcoma (EIMS), as described in our case, displays a malignant behavior with a high potential for recurrence and is associated with a poor prognosis (7,8).
Is inflammatory myofibroblastic tumor sarcoma?
Inflammatory myofibroblastic tumors usually occur in children and young adults. They are a type of soft tissue sarcoma.
What does IMT mean in medical terms?
Inflammatory Myofibroblastic Tumor (IMT)
What is an inflammatory myofibroblastic tumor?
Abstract. Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. A number of terms have been applied to the lesion, namely, inflammatory pseudotumor, fibrous xanthoma, plasma cell granuloma, pseudosarcoma,…
What is Alk-1 myofibroblastic tumor?
Keywords: ALK-1, myofibroblasts, neoplastic, reactive Introduction Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion of unknown cause. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate.
What is IMT (myofibroblasts)?
Myofibroblasts help keep the shape of organs and heal wounds. IMTs also contain a lot of immune cells, making the tumor look “inflamed” like an infection. IMT is usually benign, meaning that it is not cancer and these tumor cells usually do not travel to other parts the body. However, IMT can invade nearby tissue and cause a lot of problems.
What is IMT in lung cancer?
IMT was first observed in lungs and described by Bunn in 1939. It was named as IMT by Umiker et al. because it mimics malignant neoplasm clinically, radiologically and histopathologically.
