What is the advantage in using darbepoetin over epoetin alfa?

What is the advantage in using darbepoetin over epoetin alfa?

Darbepoetin is currently marketed by its manufacturer as having “increased potency and longer half-life” compared with epoetin, which purportedly “allows for less-frequent dosing than the previous standard of care.”3 However, until recently, there have been few reports of clinical trials directly comparing darbepoetin …

Is darbepoetin better than erythropoietin?

Safety profile of DA-α and EPO was similar. Conclusion: Our study results demonstrate that DA-α given at a reduced dose frequency is as effective and well tolerated as EPO for treating renal anemia in pre-dialysis patients with CKD.

When should you not give Aranesp?

Do not take Aranesp ® if you: Have high blood pressure that is not controlled (uncontrolled hypertension). Have been told by your healthcare provider that you have, or have ever had a type of anemia called Pure Red Cell Aplasia (PRCA) that starts after treatment with Aranesp ® or other erythropoietin medicines.

What are the side effects of the medication Aranesp?

Common side effects of Aranesp include:

  • headache,
  • body aches,
  • stomach pain,
  • cough,
  • skin rash or redness,
  • diarrhea, and.
  • injection site reactions (pain, bruising, swelling, warmth, redness, oozing, or bleeding).

What is the primary difference between epoetin and darbepoetin?

There are no clinically significant differences in the safety and efficacy of epoetin alfa (Epogen, Procrit) and darbepoetin alfa (Aranesp), the two drugs most commonly used to treat anemia in cancer patients undergoing chemotherapy or radiation treatments, according to a new report by the Agency for Healthcare …

What health problem is a possible side effect of erythropoiesis stimulating agent ESA therapy?

ESAs can cause hemoglobin to rise too high, which puts the patient at higher risk for heart attack, stroke, heart failure, and death.

Is erythropoietin and darbepoetin same?

Erythropoietin is the name of a hormone produced mainly in the kidney, which takes part in the production of red blood cells. Epoetin and darbepoetin work in a similar way to this hormone to increase the number of red blood cells and treat anaemia.

How safe is Aranesp?

Aranesp increases the risk of death, myocardial infarction, stroke, venous thromboembolism, and thrombosis of vascular access and tumor progression or recurrence. Aranesp can also lead to an increase in adverse cardiovascular events, hypertension, seizures, and severe anemia.

When should I stop taking darbepoetin?

Treatment with darbepoetin alfa injection should be stopped when your course of chemotherapy ends. A program called the ESA APPRISE Oncology Program has been set up to decrease the risks of using darbepoetin alfa injection to treat anemia caused by chemotherapy.

Are Aranesp and retacrit the same?

Epoetin alfa (Retacrit, Procrit, Epogen) is a glycoprotein that stimulates red blood cell production; whereas, darbepoetin alfa (Aranesp) stimulates erythropoiesis by the same mechanism as endogenous erythropoietin.

How do you know Epoetin alfa is working?

Your doctor will test your blood regularly—at least weekly at the beginning of your treatment—to make sure EPOGEN® is working. The test will measure your Hb or your hematocrit (hee-MAT-a-crit) levels, though most doctors measure Hb because it is a better way to check for anemia.


Back to Top