What is the difference between HbSS and HbSC?

What is the difference between HbSS and HbSC?

A child with ‘classic’ sickle cell disease has HbSS – one HbS from each parent. A child with HbSC has HbS from one parent and HbC from the other. Similarly, a child with HbS/ß-thalassemia has inherited HbS from one parent and ß- thalassemia trait from the other parent.

Are there different types of sickle cell trait?

There are different forms of sickle cell disease. They include Hb SS, Hb SC, Hb S beta-thalassemia, etc. All of these hemoglobin types cause a vaso-occlusive crisis. HbSS is the most common and severe type.

What is the most common sickle cell anemia?

When a person has two hemoglobin S genes (hemoglobin SS), the disease is called sickle cell anemia. This is the most common and often most severe type of sickle cell disease. Hemoglobin SC disease and hemoglobin Sβ thalassemia are two other common types of sickle cell disease.

What are the variations of sickle cell anemia?

Sickle cell disease is a group of disorders that affects hemoglobin , the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disease have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle , or crescent, shape.

What is the difference between HbC and HbS?

HbC has been described as being more advantageous than HbS because, even in homozygous individuals, it is usually non-fatal. However, in contrast to HbS, it does not prevent malaria due to P. vivax, and is less effective in resistance to falciparum malaria in heterozygous conditions.

What is the full form of Hbse?

Haryana Board of School Education (HBSE), Established in 1969 is now known as Board of School Education Haryana (BSEH)., is the authority which conducts the Public Examinations at Middle, Matric (Secondary or High School) and Senior Secondary School (Academic & Vocational) levels annually in the state of Haryana …

What is the difference between sickle cell SC and SS?

Unlike Hb SS, Hb SC usually does not produce significant symptoms until the teenage years. Hb SC disease may cause all the vasoocclusive complications of sickle cell anemia, but episodes are less frequent and damage is less disabling. Hemolytic anemia is moderate, and many patients exhibit moderate splenomegaly.

Why is sickle cell anemia so common in Africa?

The sickle hemoglobin mutation reached polymorphic frequency in areas of Africa—other origins of the HbS gene were in the Middle East and Indian subcontinent—where malaria was prevalent, as carriers have a survival advantage and are more likely to survive to reproduce.

Why is sickle cell anemia more common in Africa?

Sickle cell disease occurs more often among people from parts of the world where malaria is or was common. It is believed that people who carry the sickle cell trait are less likely to have severe forms of malaria.

What are people most likely to develop sickle cell anemia?

Sickle cell disease is more common in certain ethnic groups, including: People of African descent , including African-Americans (among whom 1 in 12 carries a sickle cell gene) Hispanic-Americans from Central and South America. People of Middle Eastern, Asian, Indian, and Mediterranean descent.

What is life expectancy for sickle cell anemia?

This represents a decrease of roughly 25 to 30 years in life expectancy, as compared with that of the black American population in general. Among patients with sickle cell-hemoglobin C disease, the median age at death was 60 years for males and 68 years for females.

What are the differential diagnoses for sickle cell anemia?

DIFFERENTIAL DIAGNOSIS Although a host of lesions can mimic sickle-cell disease, five should be readily considered. They include (1) bony infarction of unknown origin, (2) suppura- tive osteomyelitis, (3) chronic sclerosing osteomyelitis, (4) condensing osteitis, and (5) Gardner’s syndrome.

What is the life span of sickle cell anemia?

Patients with sickle cell-hemoglobin C disease have a life expectancy of 60 years for men and 68 years for women. People with sickle cell trait have a normal life expectancy.