What is the function of artemisinin?
What is the function of artemisinin?
Artemisinin (ARS) and its derivatives (ARSs) are recommended as the first-line antimalarial drugs for the treatment of malaria. Besides antimalarial function, its potent anti-inflammatory and immunoregulatory properties, as well as the ability to regulate oxidative stress have brought them to a prominent position.
How is artemisinin produced?
Artemisinin is naturally produced in trichomes of leaves. At the same time, transgenic hairy roots are considered a good source to harvest artemisinin. However, the absence of trichomes in hairy roots suggests that artemisinin biosynthesis is not limited to trichomes.
What is biological source and uses of artemisinin?
artemisinin, also called qinghaosu, antimalarial drug derived from the sweet wormwood plant, Artemisia annua. Artemisinin is a sesquiterpene lactone (a compound made up of three isoprene units bound to cyclic organic esters) and is distilled from the dried leaves or flower clusters of A. annua.
What type of terpene is artemisinin?
Artemisinin is a sesquiterpene lactone isolated from the aerial parts of Artemisia annua L. plants.
Why artemisinin is effective against the malarial parasite?
With the help of chemical proteomics, researchers have now shown that artemisinin kills the malaria parasite Plasmodium falciparum by indiscriminately binding to proteins in many of the organism’s key biochemical pathways.
What is the difference between Artemisia and artemisinin?
is that artemisia is (plant) any of many aromatic flowering plants of the genus artemisia , including wormwood, sagebrush, and tarragon while artemisinin is (medicine|biochemistry|organic compound) an antimalarial drug derived from the (sweet wormwood) shrub, , found as the active ingredient in traditional chinese …
Who manufactures artemisinin?
Sanofi
This report studies Artemisinin in global market, focuses on top manufacturers in global market, with sales, price, revenue and market share for each manufacturer, covering Sanofi, KPC Pharmaceuticals, Inc, Guangxi xiancaotang pharmaceutical Co. LTD, Guilin Pharmaceutical Co.
Why is it important to understand the structure and formation of artemisinin?
Clarifying mechanisms of action of artemisinins is important for understanding both how structurally related drugs, such as the fully synthetic trioxolanes, might work and the basis for the development of resistance by parasites to this class of antimalarial.
Is Artemisinin a secondary metabolite?
Historically, plant secondary metabolites, such as morphine, quinine and aspirin, have played an important role in human’s battles against diseases. The finding of artemisinin demonstrated that traditional medicines are still a rich and promising resource for discovery and development of new drugs.
What is artemisia ketone?
Artemisia ketone is a member of the class of compounds known as enones. Artemisia ketone is a berry, green, and herbal tasting compound found in sunflower and tarragon, which makes artemisia ketone a potential biomarker for the consumption of these food products.
How does Artemisinin eliminate Plasmodium falciparum the causative agent for malaria?
An alkyne-labeled artemisinin analog (red sphere) binds to proteins in the malaria parasite. With the help of chemical proteomics, researchers have now shown that artemisinin kills the malaria parasite Plasmodium falciparum by indiscriminately binding to proteins in many of the organism’s key biochemical pathways.
