What is the function of EGF?
What is the function of EGF?
Epidermal growth factor (EGF) is a common mitogenic factor that stimulates the proliferation of different types of cells, especially fibroblasts and epithelial cells. EGF activates the EGF receptor (EGFR/ErbB), which initiates, in turn, intracellular signaling.
What does EGFR gene do?
A gene that makes a protein that is involved in cell growth and cell survival. Mutated (changed) forms of the EGFR gene and protein have been found in some types of cancer, including non-small cell lung cancer. These changes may cause cancer cells to grow and spread in the body.
How does EGF stimulate cell division?
Epidermal Growth Factor (EGF) is a 6045 dalton polypeptide which stimulates the proliferation of various cell types in vitro and in vivo. EGF binds to diffusely distributed membrane receptors which rapidly cluster primarily on coated pits areas on the plasma membrane.
What activates EGFR?
According to the “ligand-induced dimerization model”, EGFR is activated by the ligand-induced dimerization of the receptor monomer, which brings intracellular kinase domains into close proximity for trans-autophosphorylation to initiate downstream signaling cascades.
Does everyone have the EGFR gene?
An EGFR mutation is present in roughly 15 percent of people with lung cancer in the United States, though this number increases to 35 to 50 percent in people of Eastern Asian descent. It is most commonly found in people with the type of non-small cell lung cancer called lung adenocarcinoma.
What does the EGFR gene do?
Learn more The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell.
What does the EGF gene stand for?
GeneCards Summary for EGF Gene. EGF (Epidermal Growth Factor) is a Protein Coding gene. Diseases associated with EGF include Hypomagnesemia 4, Renal and Familial Primary Hypomagnesemia With Normocalciuria And Normocalcemia.
What is the difference between EGF and EF-G?
Not to be confused with EF-G. Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-k Da and has 53 amino acid residues and three intramolecular disulfide bonds.
Is EGF-EGFR complex translocation to the nucleus related to cancer?
The quantitative study of epidermal growth factor (EGF) -epidermal growth factor receptor (EGFR) complex translocation to the nucleus may help to unravel its roles in health and pathological conditions, such as cancer.
