What is the function of FGF2?
What is the function of FGF2?
Fibroblast growth factor 2 (FGF2), also known as basic fibroblast growth factor (bFGF) prevents endothelial cells from undergoing cell death and promotes endothelial cell proliferation and angiogenesis [142].
What produces FGF?
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function lead to a range of developmental defects.
Is FGF a receptor?
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells. This review summarizes the structure of FGFR, especially its kinase domain, and the development of small molecule FGFR inhibitors.
How many FGF receptors are there?
four receptors
The fibroblast growth factor receptor (FGFR) family includes four receptors that bind 18 ligands called fibroblast growth factors, using heparin as a co-factor1,2,3,4.
How many FGF are there?
The FGF family comprises 23 members, although there are only 18 FGFR ligands. Four family members do not bind with FGFR as FGF homologous factors (FGF11, FGF12, FGF13, and FGF14) and are more correctly referred to as FGF homologous factors.
What is the meaning of FGF?
FGF
| Acronym | Definition |
|---|---|
| FGF | Fine Girl Friday |
| FGF | Feel-Good Factor |
| FGF | Fake Girlfriend |
| FGF | Federación Gallega de Fútbol (Spain) |
Is FGF a ligand?
FGF ligands are polypeptide growth factors that regulate several developmental processes including cellular proliferation, differentiation, and migration, morphogenesis, and patterning. FGF-FGFR signaling is also critical to the developing axial and craniofacial skeleton.
What is FGF pathway?
Fibroblast growth factors (FGF) and their receptors serve many functions in both the developing and adult organism. FGF signaling generally follows one of three transduction pathways: RAS/MAP kinase, PI3/AKT, or PLCγ. Each pathway likely regulates specific cellular behaviors.
What are the isoforms of fatfgf2?
FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways.
What does FGF2 stand for?
FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions.
What is the difference between the 18 kDa and 24 kDa isoform?
The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4.
Where is the FGF2 gene located on the chromosome?
In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth.
