What is the most common cause of secondary osteoporosis?

What is the most common cause of secondary osteoporosis?

The most common causes of secondary osteoporosis include: Endocrinopathies (hyperthyroidism, hypogonadism, hypopituitarism, primary hyperparathyroidism, diabetes mellitus, eating disorders, growth hormone deficiency and acromegaly)

Do Mineralocorticoids cause osteoporosis?

Causes and Risk Factors Corticosteroids tend to both reduce the body’s ability to absorb calcium and increase how fast bone is broken down. The more of these drugs you take and the longer you take them, the greater your risk of developing osteoporosis.

Does prednisone affect hyperparathyroidism?

Steroids work directly on target tissues in bone to increase resorption and decrease formation. Their effects on calcium result in an indirect increase in destruction by triggering the parathyroid glands to increase the secretion of parathyroid hormone (PTH). This condition is known as secondary hyperparathyroidism.

How do you treat corticosteroid induced osteoporosis?

The first-line drugs for treatment of glucocorticoid-induced osteoporosis include bisphosphonates: alendronate and risedronate, while zoledronate or teriparatide should be considered as the second option.

Can secondary osteoporosis be reversed?

Much like primary osteoporosis, there is no cure for secondary osteoporosis.

What medications are commonly associated with secondary osteoporosis?

The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.

Can you fix low bone density?

If you have low bone mass, there are things you can do to help slow down bone loss. These include eating foods rich in calcium and vitamin D and doing weight-bearing exercise such as walking, tennis, or dancing. In some cases, your doctor may prescribe medicines to prevent osteoporosis.

Does prednisone lower your calcium levels?

Serum calcium decreased during prednisone (p<0.05), but when prednisone was given together with calcium, an increase of serum calcium was found (p< 0.05). It is concluded that 10 mg prednisone/day decreases bone formation, as shown by its effect on osteocalcin, while no influence is seen on bone resorption.

Can prednisone cause high calcium levels?

Prednisolone induces an increase in serum calcium concentration: possible involvement of the kidney, the bone, and the intestine. Calcif Tissue Int.

Can steroid-induced osteoporosis be reversed?

The accompanying biochemical changes, particularly the marked increase in serum osteocalcin levels, confirm that enhanced bone formation occurred during the recovery phase. These findings suggest that steroid-induced osteoporosis can be reversed at least in young persons.