What is the use of kaempferol?

What is the use of kaempferol?

Kaempferol reduces the risk of chronic diseases, especially cancer. Kaempferol augments human body’s antioxidant defense against free radicals. Kaempferol modulates apoptosis, angiogenesis, inflammation, and metastasis.

Which drug has chemical constituent is kaempferol?

Plants that are known to contain kaempferol include Aloe vera, Coccinia grandis, Cuscuta chinensis, Euphorbia pekinensis, Glycine max, Hypericum perforatum, Pinus sylvestris, Moringa oleifera, Rosmarinus officinalis, Sambucus nigra, and Toona sinensis, and Ilex.

What is quercetin kaempferol?

Quercetin and kaempferol are among the most ubiquitous polyphenols in fruit and vegetables. Most of the quercetin and kaempferol in plants is attached to sugar moieties rather than in the free form. The types and attachments of sugars impact bioavailability, and thus bioactivity.

Does green tea have kaempferol?

Among the flavonols in green tea, kaempferol has many biological activities but kaempferol of plant origin is too expensive to be used in commercial products. Recently, we confirmed that green tea seed (GTS) contained a reasonable amount of kaempferol glycoside.

Is kaempferol antioxidant?

Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases, especially cancer.

Where is kaempferol found?

Kaempferol is a natural flavonol, a class of flavonoid, found in many fruits vegetables and herbs, including grapes, tomatoes, broccoli, tea, and ginkgo biloba leaves.

Does black tea contain kaempferol?

Black tea was by far the major source of total catechin (80%), kaempferol (70%), and myricetin (78%) and contributed significantly to intake of catechin (35%), epicatechin (46%), total flavonol (46%), and quercetin (35%).

What is the biosynthesis of kaempferol?

The biosynthesis of kaempferol occurs in four major steps: Phenylalanine is converted into 4-coumaroyl-CoA 4-coumaroyl-CoA combines with three molecules of malonyl-coA to form naringenin chalcone (tetrahydroxychalcone) through the action of the enzyme chalcone synthase

What is the biosynthesis pathway of kaempferol in yeast Saccharomyces cerevisiae?

In this study, the biosynthesis pathway of kaempferol was constructed in the budding yeast Saccharomyces cerevisiae to produce kaempferol de novo, and several biological measures were taken for high production. Firstly, a high efficient flavonol synthases (FLS) from Populus deltoides was introduced into the biosynthetic pathway of kaempferol.

How does kaempferol interact with estrogen receptors?

Estrogen receptors are important in both maintaining a normal mammary gland, and in the development of primary and secondary breast cancer. Kaempferol has been shown to interact with the estrogen receptor pathway and alter signaling in order to help slow growth.

How do you make kaempferol from glucose?

Firstly, a high efficient flavonol synthases (FLS) from Populus deltoides was introduced into the biosynthetic pathway of kaempferol. Secondly, a S. cerevisiae recombinant was constructed for de novo synthesis of kaempferol, which generated about 6.97 mg/L kaempferol from glucose.