What should I monitor with sitagliptin?
What should I monitor with sitagliptin?
Before starting and during treatment with sitagliptin, your doctor may check your:
- blood sugar levels.
- glycosylated hemoglobin (A1C) levels (measures your blood sugar control over the last 2–3 months)
- cholesterol.
- kidney function.
What are the most common side effects of SGLT2 inhibitors?
Common SGLT2 side effects include:
- Urinary tract infection.
- Female and male genital yeast infections.
- Upper respiratory tract infections.
- Increased urination.
- Dyslipidemia (increase in cholesterol)
- Joint pain.
- Nausea.
- Thirst.
What does sitagliptin do to your body?
Sitagliptin works by increasing the amount of insulin that your body makes. Insulin is the hormone that controls sugar levels in your blood. You take sitagliptin once a day. The most common side effect of sitagliptin is headaches.
Can sitagliptin be taken at night?
Take Januvia (generic name: sitagliptin) once a day exactly as your doctor tells you. You can take it in the morning or evening, but it’s best to get into a routine of taking it at the same time each day.
What is the difference between sitagliptin and vildagliptin?
The reason for the differences in drug efficacy (mean blood glucose level and MAGE) observed in this study is considered to be that sitagliptin 50 mg daily results in less than 70% suppression of DPP-4 activity over 24 h [20] whereas vildagliptin 50 mg twice daily results in 80% or greater suppression of DPP-4 activity …
What are the negative effects of JANUVIA?
The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with metformin and rosiglitazone (Avandia ®).
Do SGLT2 inhibitors cause hypoglycemia?
SGLT2 inhibitors only lower plasma glucose levels by blocking reabsorption of filtered glucose, which falls as plasma levels fall. Thus, they do not usually cause hypoglycemia in the absence of therapies that otherwise cause hypoglycemia. SGLT2 inhibitors modestly decrease blood pressure and weight [1].
Does canagliflozin cause lactic acidosis?
IMPORTANT SAFETY INFORMATION for INVOKANA®, INVOKAMET® (canagliflozin/metformin HCl), and INVOKAMET® XR. Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias.
Why is januvia bad for you?
The most common side effects of JANUVIA are upper respiratory tract infection, stuffy or runny nose and sore throat, and headache. Before you take JANUVIA, tell your doctor about all of your medical conditions. JANUVIA can cause serious side effects, including pancreatitis, which may be severe and lead to death.
Is sitagliptin short acting?
Insulin glargine is a long-acting insulin given once a day. Sitagliptin belongs to a class of drugs called dipeptydil peptidase 4 (DPP-4) inhibitors.
What are the side effects of vildagliptin?
Some of the common and major side effects of Vildagliptin are:
- Headache.
- Cough.
- Constipation.
- Sweating.
- Hypoglycaemia.
- Weakness.
- Excessive sweating.
- Heartburn.
What is difference between linagliptin and vildagliptin?
The vildagliptin group had the lowest insulin dose. The dose in the linagliptin group, though not as low as in the vildagliptin group, was lower than in the sitagliptin group (P = 0.014). At week 12 the dose was 20.71 ± 12.36 U (vildagliptin), 27.34 ± 13.46 U (sitagliptin) and 24.81 ± 15.08 U (linagliptin).
How do you take sitagliptin?
Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. It is taken by mouth.
Does sitagliptin cause pancreatitis?
Sitagliptin may cause an increased risk in the development of pancreatitis. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other oral hypoglycemic agents.
Is sitagliptin expressed in human breast milk?
Sitagliptin is excreted in the milk of rats but it is not known if it would also be expressed in human breast milk Label. Because many drugs are expressed in human breast milk, the risk and benefit of prescribing the medication must be considered Label. There is currently a lack of safety and effectiveness data in pediatric patients Label.
What is the KOC value of sitagliptin?
Using a structure estimation method based on molecular connectivity indices(1), the Koc of sitagliptin can be estimated to be 3.43X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that sitagliptin is expected to be immobile in soil.
