What type of molecule is imatinib?

What type of molecule is imatinib?

Imatinib is a member of the class of small molecule tyrosine kinase inhibitors with selectivity for the Abl kinase. Imatinib is a potent competitive inhibitor of ATP binding to Abl kinase, as well as to the c-Kit and PDGF receptor tyrosine kinases.

How was imatinib designed?

Imatinib was developed by rational drug design. After the Philadelphia chromosome mutation and hyperactive bcr-abl protein were discovered, the investigators screened chemical libraries to find a drug that would inhibit that protein. With high-throughput screening, they identified 2-phenylaminopyrimidine.

What is the mechanism of imatinib?

Opin. Oncol., 15: 10-15, 2003. Mohamed A. N., Pemberton P., Zonder J., Schiffer C. A. The effect of imatinib mesylate on patients with philadelphia chromosome-positive chronic myeloid leukemia with secondary chromosomal aberrations. Clin.

Where is imatinib manufactured?

4-6 Imatinib first became available in its generic form in the United States in February 2016. 7 Sun Pharmaceuticals from India manufactured the first generic form of imatinib marketed in the United States.

Is imatinib a biologic?

Imatinib is a targeted cancer drug (biological therapy) and is also known by its brand name Glivec (pronounced glee-vec). It is a treatment for many different types of cancer.

Is imatinib a chemotherapy?

Imatinib (Gleevec®) is a Chemotherapy Regimen for Chronic Myeloid Leukemia (CML)

What is the generic name for imatinib?

Gleevec is the trade name for the generic drug name Imatinib Mesylate. STI-571 is another name for Imatinib Mesylate. In some cases, health care professionals may use the trade name Gleevec or other name STI-571 when referring to the generic drug name Imatinib Mesylate. Drug type: Gleevec is a targeted therapy.

Who owns imatinib?

Imatinib has become the bestselling drug for Novartis, generating $4.7 billion worldwide in 2015 and $2.5 billion in the United States.

What does imatinib stand for?

IM stands for Imatinib Mesylate (oncology) Suggest new definition. This definition appears very frequently and is found in the following Acronym Finder categories: Science, medicine, engineering, etc.

What does imatinib mesylate mean?

Imatinib Mesylate is the mesylate salt of imatinib , a tyrosine kinase inhibitor with antineoplastic activity.

What is imatinib mesylate?

Imatinib Mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity.

Is imatinib chemo?

In brief: Yes. Gleevec, otherwise known by its generic name imatinib, is considered a chemotherapy treatment for cml, and a highly successful one. It is sometimes referred to as targeted therapy, or biologic therapy, because it targets the classic mutation (alteration) in CML cancer cells that causes them to become cancer cells.

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