Where are P2X receptors found?
Where are P2X receptors found?
glia
P2X receptors are found on glia and neurons. On astrocytes in mouse cortex, the predominant form is a P2X1/P2X5 heteromer [45], whereas microglia express mostly the P2X7 receptor [40,46]. On neurons in the hippocampus, P2X4 receptors are located at the periphery of the post-synaptic density [47].
How many P2Y receptors are there?
eight
There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y receptors are widely expressed and play important roles in physiology and pathophysiology.
Which purine receptor is an ion channel?
Purinergic P2X Receptor P2X receptors
P2X receptors (P2X1R–P2X7R) are a eukaryotic family of seven adenosine triphosphate-gated (ATP-gated) ion channels found in cell surface membranes and intracellular vacuoles.
What do P2Y receptors do?
P2Y receptors mediate responses including vasodilation, blood clotting, and immune response. Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.
What are purines vs pyrimidines?
Purines and pyrimidines are the nitrogen bases that hold DNA strands together through hydrogen bonds. The purines in DNA are adenine and guanine, the same as in RNA. The pyrimidines in DNA are cytosine and thymine; in RNA, they are cytosine and uracil.
What is ionotropic and metabotropic receptors?
Ionotropic and metabotropic receptors are two types of receptors that function in membrane transport and signal transduction. Ionotropic receptors bind to ionic ligands such as K+, Na+, Cl–, and Ca2+. Metabotropic receptors bind with non-ionic ligands such as chemical receptors or G protein-coupled receptors.
What are P2Y inhibitors?
P2Y12 receptor blockers are another group of antiplatelet drugs. This group of drugs includes: clopidogrel, ticlopidine, ticagrelor, prasugrel, and cangrelor.
