Which mutation is associated with zidovudine?
Which mutation is associated with zidovudine?
The T215Y mutation is a primary mutation observed after AZT treatment. T215Y alone reduces the susceptibility for AZT ≈16-fold and is the first mutation seen in the majority of patients receiving combination therapy with AZT and other nucleoside analogs such as didanosine (ddI) or zalcitabine (ddC) (2, 3).
What is the difference between NRTIs and NNRTIs?
So NRTIs are like another zip giving the zipper another track to follow. NNRTIs work by sitting in a binding site in the virus structure and this is a bit like having an object that blocks the teeth of the zipper, so the zipper cannot get past the block.
Is Lamivudine an antiviral?
Lamivudine is a prescription nucleoside reverse transcriptase inhibitor (NRTI) that is used in combination with other drugs as antiviral treatment for human immunodeficiency virus type-1 (HIV-1) and as a monotherapy for hepatitis B virus (HBV).
What do we know about NRTI susceptibility mutations?
Mutations in bold reduce NRTI susceptibility or virological response. Mutations in plain text contribute to reduced susceptibility in combination with other NRTI-resistance mutations. M184V/I are selected by 3TC/FTC and reduce susceptibility to these drugs >100-fold.
What causes resistance to nucleoside reverse transcriptase inhibitors (NRTIs)?
Resistance and cross-resistance to nucleoside reverse transcriptase inhibitors (NRTIs) is becoming better understood. This is a complex phenomenon, which involves mutations that occur under the selective pressure of drugs and interactions between mutations.
Is K65R the most common NRTI-associated resistance mutation?
Nonetheless, regardless of subtype, K65R is the most common NRTI-associated resistance mutation other than M184V to develop in patients receiving a TDF-containing regimen. There has also been no evidence that patients with subtype C viruses are at higher risk of developing VF on a TDF-containing regimen.
What is the mechanism of resistance to NRTI?
Mechanisms of NRTI resistance. One mechanism for resistance to NRTIs is discrimination, whereby the reverse transcriptase (RT) enzyme is able to avoid binding of the NRTI, while retaining the ability to recognise the analogous natural deoxynucleoside triphosphate (dNTP) substrate.
