Which of the following are members of the immunoglobulin superfamily?

Which of the following are members of the immunoglobulin superfamily?

Members of the Immunoglobulin superfamily include vascular and neural cell adhesions molecules (VCAM and NCAM), intercellular adhesion molecules (ICAM) and the Nectins and nectin-like (Necl) proteins.

What is immunoglobulin supergene family?

The immunoglobulin supergene family is “the group of proteins that have immunoglobulin-like domains, including histocompatibility antigens, the T-cell antigen receptor, poly-IgR, and other proteins involved in the vertebrate immune response (17).”

Is CD8 part of the IG super gene family?

This class of IgSF members is composed of CD4, CD8 and CD19. These proteins also interact with MHC molecules.

What are proteins that belong to the family of immunoglobulins?

Included are CD2, CD3, CD4, CD7, CD8, CD28, T cell receptor (TCR), MHC class I and MHC class II molecules, leukocyte function-associated antigen 3 (LFA-3), the IgG receptor, and a dozen other proteins.

Is TCR immunoglobulin?

The TCR is a member of the immunoglobulin superfamily, a large group of proteins involved in binding, recognition, and adhesion; the family is named after antibodies (also called immunoglobulins).

What are the 5 different immunoglobulins?

The five primary classes of immunoglobulins are IgG, IgM, IgA, IgD and IgE. These are distinguished by the type of heavy chain found in the molecule.

How many domains do antibodies have?

Figure. Antibodies all have the same basic structure consisting of two heavy and two light chains forming two Fab arms containing identical domains at either end attached by a flexible hinge region to the stem of the antibody, the Fc domain, giving the classical ‘Y’ shape.

What is Ig like domain?

The immunoglobulin (Ig)-like domain is a protein domain that is similar in amino acid sequence and structure to the Ig domains of immunoglobulins (Edelman, 1987; Williams & Barclay, 1988). Structurally, Ig domains possess a distinctive immunoglobulin fold composed of 70–110 amino acids (Fig.

Are selectins lectins?

All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding. Selectins bind to sugar moieties and so are considered to be a type of lectin, cell adhesion proteins that bind sugar polymers.

What is the IgSF superfamily composed of?

The IgSF superfamily is composed of surface antigen receptors, co-receptors of the immune system, cell adhesion molecules, some cytokine receptors and molecules involved in antigen presentation to lymphocytes. Most of the IgSF members play roles in the immune system.

What are the IGSF members of the TCR family?

This class of IgSF members contains Class I MHC (major histocompatibility complex), Class II MHC and beta-2 microglobulin as ligands for TCRs. Antigen receptor accessory molecules . This class of IgSF members contains CD3-γ, -δ and -ε chains, CD79a and CD79b.

What are the members of the immunoglobulin superfamily?

Molecules are categorized as members of this superfamily based on shared structural features with immunoglobulins (also known as antibodies); they all possess a domain known as an immunoglobulin domain or fold. Members of the IgSF include cell surface antigen receptors, co-receptors and co-stimulatory molecules…

What is the structural domain of the IGSF protein?

Proteins of the IgSF possess a structural domain known as an immunoglobulin (Ig) domain. Ig domains are named after the immunoglobulin molecules.